{"id":"W4409427510","doi":"10.1186/s40635-025-00750-y","title":"Intracranial response to positive end-expiratory pressure is influenced by lung recruitability and gas distribution during mechanical ventilation in acute brain injury patients: a proof-of-concept physiological study","year":2025,"lang":"en","type":"article","venue":"Intensive Care Medicine Experimental","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Norsk Institutt for Vannforskning; Uppsala Universitet; Vetenskapsrådet; Akademiska Sjukhuset; Svenska Läkaresällskapet; Hjärt-Lungfonden; Svenska Sällskapet för Medicinsk Forskning","keywords":"Medicine; Positive end-expiratory pressure; Intracranial pressure; Oxygenation; Anesthesia; Oxygenation index; Mechanical ventilation; Cardiology; Cerebral perfusion pressure; Ventilation (architecture); Lung; Internal medicine; Cerebral blood flow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000939486,0.0004706474,0.0005368039,0.0002082497,0.0002229131,0.0004467602,0.0004037426,0.0003560864,0.001362687],"category_scores_gemma":[0.001013909,0.0001935013,0.0005070647,0.0001208689,0.0008038573,0.0004338115,0.000516242,0.000937445,0.0001918066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521891,"about_ca_system_score_gemma":0.0005455925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002569222,"about_ca_topic_score_gemma":0.0002217479,"domain_scores_codex":[0.9996686,0.00009250519,0.00001818754,0.0000636113,0.00008250289,0.00007461666],"domain_scores_gemma":[0.9994654,0.0001565785,0.0001241889,0.0000563467,0.00008592731,0.0001116695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02871859,0.01374107,0.04664509,0.0009674596,0.0003455223,0.0007129482,0.0008062856,0.001355314,0.8578019,0.0003301794,0.001195847,0.04737989],"study_design_scores_gemma":[0.003568712,0.2253542,0.4544688,0.0001303253,0.001014936,0.002972121,0.001458687,0.01492785,0.2915697,0.0006128551,0.003779615,0.0001421075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978595,0.0004007881,0.001287431,0.00005221122,0.00003133078,0.0001233509,0.000073366,0.00001655708,0.0001554912],"genre_scores_gemma":[0.9968129,0.0003522739,0.001974056,0.0001002874,0.00007160707,0.0003500498,0.000171605,0.000006474502,0.0001606457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362687,"threshold_uncertainty_score":0.004968524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079543460237647,"score_gpt":0.3298886081937576,"score_spread":0.3190931735913811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}