{"id":"W4409432589","doi":"10.3390/life15040640","title":"Preclinical Animal Models to Investigate the Role of Nav1.7 Ion Channels in Pain","year":2025,"lang":"en","type":"review","venue":"Life","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Sodium channel; NAV1; Chronic pain; Medicine; Neuropathic pain; Disease; Bioinformatics; Neuroscience; Downregulation and upregulation; Adverse effect; Pain sensation; Sensation; Pharmacology; Anesthesia; Gene; Biology; Internal medicine; Physical therapy; Genetics; Chemistry; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005277523,0.0007031414,0.001137387,0.001321221,0.0001757648,0.000554662,0.0006823881,0.0007583812,0.004139728],"category_scores_gemma":[0.0004464275,0.0001629496,0.0006979586,0.0007375459,0.0002507561,0.0006193949,0.0003737789,0.001385496,0.001732229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002858066,"about_ca_system_score_gemma":0.0005658905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005246288,"about_ca_topic_score_gemma":0.001340546,"domain_scores_codex":[0.9998623,0.00002326247,0.00001881751,0.00002080576,0.00005775709,0.00001692018],"domain_scores_gemma":[0.9998271,0.00007606195,0.00002716499,0.000007417222,0.00004727286,0.00001494642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002801368,0.0003112928,0.0003380571,0.03900344,0.0002784579,0.000302101,0.00006520408,0.0005320026,0.0283431,0.005166935,0.02360581,0.9017735],"study_design_scores_gemma":[0.00008772124,0.0009812244,0.002111054,0.007085216,0.0006484266,0.002025789,0.00008179287,0.0002302229,0.008381514,0.00240541,0.9759191,0.00004249323],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001174395,0.9935002,0.0007372869,0.0003396249,0.0002845441,0.00004322419,0.0001945078,0.00003631617,0.003689945],"genre_scores_gemma":[0.003369658,0.9939637,0.0007037889,0.0002926231,0.00009530953,0.00004169968,0.0002181719,0.000004629667,0.001310387],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004139728,"threshold_uncertainty_score":0.01384872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1207850022602543,"score_gpt":0.3792815119521842,"score_spread":0.2584965096919299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}