{"id":"W4409433150","doi":"10.1017/s1092852925000276","title":"Urgency to treat and early optimized treatment in major depressive disorder: consequences of delayed treatment, barriers to implementation, and practical strategies for clinicians","year":2025,"lang":"en","type":"review","venue":"CNS Spectrums","topic":"Treatment of Major Depression","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Queen's University; Canadian Mental Health Association; Lakehead University; University of Alberta; Laurentian University; McGill University; University of Ottawa; START Clinic; Homewood Research Institute; University of Toronto; University of Calgary","funders":"Allergan; Lundbeck Canada; Otsuka Canada Pharmaceutical; Idorsia Pharmaceuticals; H. Lundbeck A/S; Otsuka Pharmaceutical; National Natural Science Foundation of China; Servier; Pfizer; Fondation Brain Canada; Canadian Institutes of Health Research; Sunovion; Eisai; Sanofi","keywords":"Medicine; Major depressive disorder; Psychiatry; Psychotherapist; Intensive care medicine; Psychology; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001911304,0.0005035563,0.001132767,0.001196003,0.0003627617,0.001520897,0.0008905169,0.001161763,0.002243234],"category_scores_gemma":[0.004556905,0.0002431074,0.0008691488,0.001277106,0.0003973331,0.001070318,0.0007367668,0.001895505,0.0005366829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009847967,"about_ca_system_score_gemma":0.003302914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003927195,"about_ca_topic_score_gemma":0.009724889,"domain_scores_codex":[0.9992213,0.0003144856,0.0001572843,0.00005923566,0.0002012487,0.00004642845],"domain_scores_gemma":[0.9982784,0.001134933,0.0002170577,0.00002751018,0.0002761634,0.00006585812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000605534,0.00005877146,0.0003203343,0.0568989,0.0002452148,0.0001047293,0.0002462507,0.0002508213,0.000209269,0.003628859,0.01843621,0.91954],"study_design_scores_gemma":[0.0001008269,0.0002341546,0.004031031,0.153688,0.001110594,0.001744896,0.0008106958,0.0003508475,0.0002226228,0.004152902,0.8335102,0.00004320632],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001509691,0.9981027,0.00007620091,0.0009945551,0.0001051716,0.000007853417,0.00001063076,0.000004095128,0.0005479059],"genre_scores_gemma":[0.001430867,0.9975168,0.0003624048,0.0004437616,0.00006124213,0.00001322929,0.00001525537,0.000001437813,0.0001550847],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003927195,"threshold_uncertainty_score":0.01010805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04731879566804167,"score_gpt":0.4290565390407913,"score_spread":0.3817377433727496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}