{"id":"W4409449256","doi":"10.1093/brain/awaf135","title":"Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University Health Network; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"Parkinsonfonden; National Institutes of Health; Rossy Foundation; Novo Nordisk; Eisai; Multiple System Atrophy Coalition; University of Cambridge; Johns Hopkins University; Sun Pharma; Fondation Brain Canada; Family Larsson‐Rosenquist Foundation; Biogen; Canadian Institutes of Health Research; Parkinson Canada; Edmond J. Safra Philanthropic Foundation; Krembil Foundation; Canada Foundation for Innovation; Ontario Research Foundation; Eli Lilly and Company","keywords":"Progressive supranuclear palsy; Cytotoxic T cell; Substantia nigra; Pathology; Tegmentum; Microglia; Parkinson's disease; CD8; Neuropathology; Biology; Midbrain; Neuroscience; Medicine; Immunology; Central nervous system; Inflammation; Immune system; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365885,0.0001941893,0.0003686919,0.0001044007,0.00006373778,0.00001552128,0.0001091456,0.0001250518,0.0002612051],"category_scores_gemma":[0.0003461345,0.0001431281,0.0001756372,0.0002654415,0.0001007056,0.00002897236,0.00007807231,0.0001679242,0.0000833365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003323816,"about_ca_system_score_gemma":0.0001076863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006073831,"about_ca_topic_score_gemma":0.000001922523,"domain_scores_codex":[0.9988294,0.0001354459,0.0001845229,0.0003742175,0.0002188307,0.0002575408],"domain_scores_gemma":[0.9992545,0.0001182369,0.00008777472,0.0003302347,0.00005744596,0.0001517781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005138907,0.006885083,0.07158256,0.001173554,0.0008116721,0.02136284,0.0006670485,0.000002491623,0.7462332,0.01514481,0.06462441,0.0663734],"study_design_scores_gemma":[0.009022444,0.002412429,0.7615224,0.0009653851,0.00059202,0.0003287636,0.0001906398,0.0001523945,0.1121334,0.002980785,0.1092604,0.0004391056],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893562,0.0005892715,0.00005107378,0.003630648,0.0001189661,0.0006791516,0.00007637312,0.00008528974,0.005413077],"genre_scores_gemma":[0.992989,0.00001352701,0.0008488824,0.002009039,0.00004625671,0.00004866278,0.00004240609,0.00002007256,0.003982151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6899398,"threshold_uncertainty_score":0.5836594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042116332398711,"score_gpt":0.281310255158506,"score_spread":0.2708890918345189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}