{"id":"W4409449256","doi":"10.1093/brain/awaf135","title":"Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University Health Network; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"Parkinsonfonden; National Institutes of Health; Rossy Foundation; Novo Nordisk; Eisai; Multiple System Atrophy Coalition; University of Cambridge; Johns Hopkins University; Sun Pharma; Fondation Brain Canada; Family Larsson‐Rosenquist Foundation; Biogen; Canadian Institutes of Health Research; Parkinson Canada; Edmond J. Safra Philanthropic Foundation; Krembil Foundation; Canada Foundation for Innovation; Ontario Research Foundation; Eli Lilly and Company","keywords":"Progressive supranuclear palsy; Cytotoxic T cell; Substantia nigra; Pathology; Tegmentum; Microglia; Parkinson's disease; CD8; Neuropathology; Biology; Midbrain; Neuroscience; Medicine; Immunology; Central nervous system; Inflammation; Immune system; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002170023,0.0005038055,0.0003913512,0.001019972,0.0003376107,0.0003942904,0.0002114246,0.0002961846,0.001562355],"category_scores_gemma":[0.0004825987,0.0001803366,0.0001671759,0.0003208729,0.0004508678,0.0001620115,0.0003401324,0.0003158742,0.0002299314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002201789,"about_ca_system_score_gemma":0.0001767684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332369,"about_ca_topic_score_gemma":0.001612696,"domain_scores_codex":[0.9998653,0.00002260384,0.00001724273,0.00003821573,0.00003674753,0.00001992945],"domain_scores_gemma":[0.9997289,0.00005262792,0.0001010519,0.00002013053,0.00004267808,0.0000546586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003115511,0.0003650495,0.8362253,0.0002644077,0.0001514702,0.0432599,0.001021492,0.0003316603,0.07953133,0.000233145,0.0004431088,0.03505755],"study_design_scores_gemma":[0.00004645601,0.0007108956,0.9534239,0.00003645182,0.00008235801,0.04014774,0.0002518341,0.0003848558,0.004161444,0.0001885248,0.0005571477,0.000008419742],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997875,0.0005950924,0.0002254281,0.00002261994,0.000004266315,0.00001128415,0.00005000633,0.00002218006,0.001194198],"genre_scores_gemma":[0.999267,0.0001814387,0.0001103978,0.00002277413,0.000006302823,0.000006417617,0.00006608057,0.000001885569,0.000337702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001562355,"threshold_uncertainty_score":0.005226612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042116332398711,"score_gpt":0.281310255158506,"score_spread":0.2708890918345189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}