{"id":"W4409450229","doi":"10.1101/2025.04.09.647804","title":"Nucleus raphe magnus serotonin neurons bidirectionally control spinal mechanical pain transmission","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Neuroscience; Serotonergic; Dorsal raphe nucleus; Optogenetics; Nucleus raphe magnus; Raphe nuclei; Nociception; Serotonin; Stimulation; Psychology; Medicine; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006379573,0.0001662561,0.0001439798,0.0001033784,0.00008737926,0.0002128762,0.0001354408,0.0001870321,0.001047298],"category_scores_gemma":[0.00007384286,0.0000746579,0.000103133,0.00005497566,0.0002034987,0.000151583,0.000174779,0.0002457938,0.0003247775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734958,"about_ca_system_score_gemma":0.0001357626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000581953,"about_ca_topic_score_gemma":0.0009571512,"domain_scores_codex":[0.9999521,0.00000632197,0.00000259463,0.000009645821,0.00001361814,0.00001568182],"domain_scores_gemma":[0.999961,0.000006474523,0.00001337362,0.000005132052,0.000006486742,0.000007537867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004106947,0.000005252101,0.0001513761,0.00002899226,0.000002861158,0.00004018859,0.000009265538,0.00006234042,0.9965223,0.0002389554,0.00005783411,0.0028396],"study_design_scores_gemma":[0.0000231942,0.0002305055,0.01881493,0.00002819442,0.00002659857,0.0003335892,0.00007931589,0.00422065,0.9728596,0.000599914,0.002775444,0.000008105441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780769,0.003460987,0.0122682,0.0003550431,0.00006684843,0.0000288693,0.0002048617,0.0002427389,0.005295608],"genre_scores_gemma":[0.9934909,0.0008873229,0.002878264,0.00006590864,0.00001074079,0.00001893613,0.00005356149,0.0000159593,0.002578357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047298,"threshold_uncertainty_score":0.003503501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262492355889226,"score_gpt":0.2398020960590471,"score_spread":0.2271771725001548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}