{"id":"W4409459153","doi":"10.1099/mic.0.001551","title":"Transcription factors DksA and PsrA are synergistic contributors to Legionella pneumophila virulence in Acanthamoeba castellanii protozoa","year":2025,"lang":"en","type":"article","venue":"Microbiology","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Legionella pneumophila; Regulon; Stringent response; Protozoa; Microbiology; Virulence; Pathogen; Genetics; Transcription factor; Cell biology; Phenotype; Gene; Bacteria; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085556,0.0002425701,0.0003207799,0.0002099109,0.0001074713,0.00003035421,0.0002534743,0.0003261586,0.00001148518],"category_scores_gemma":[0.000117148,0.0002175775,0.00006622892,0.000247822,0.0002030342,0.000004694006,0.0001516475,0.0002095959,0.00001353188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005124165,"about_ca_system_score_gemma":0.0001017922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002296776,"about_ca_topic_score_gemma":0.0005935358,"domain_scores_codex":[0.9983655,0.0001504922,0.0003009258,0.0006290563,0.00004833839,0.000505688],"domain_scores_gemma":[0.9994295,0.00003896058,0.00005925861,0.0002822576,0.00008154134,0.0001084708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001737718,0.00005723622,0.03026774,0.00005196058,0.00002853567,0.00001953021,0.00007848462,0.00002632907,0.9676491,0.0001252587,0.001163932,0.0003581009],"study_design_scores_gemma":[0.00153268,0.0004651339,0.02733932,0.0001324596,0.00002289527,0.00005741813,0.0004487838,0.000029443,0.8824769,0.0001058069,0.08689068,0.0004985254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964879,0.0006224945,0.0003832768,0.001011972,0.0002425022,0.0008063592,0.00009547915,0.00001551836,0.000334486],"genre_scores_gemma":[0.9979972,0.0002115863,0.0000311156,0.0005483553,0.00007062358,0.00007802372,0.0001462006,0.00001661272,0.0009003159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08572675,"threshold_uncertainty_score":0.8872554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047523235773127,"score_gpt":0.2611939155994771,"score_spread":0.2507186832417458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}