{"id":"W4409459153","doi":"10.1099/mic.0.001551","title":"Transcription factors DksA and PsrA are synergistic contributors to Legionella pneumophila virulence in Acanthamoeba castellanii protozoa","year":2025,"lang":"en","type":"article","venue":"Microbiology","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Legionella pneumophila; Regulon; Stringent response; Protozoa; Microbiology; Virulence; Pathogen; Genetics; Transcription factor; Cell biology; Phenotype; Gene; Bacteria; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001726389,0.0007033699,0.0004289538,0.0003207475,0.0002075775,0.0004861522,0.0002230694,0.0003303986,0.0008433886],"category_scores_gemma":[0.0001996501,0.0003798507,0.0003606573,0.0001414859,0.0004740196,0.0002212596,0.0006174031,0.0005445648,0.0004652677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000421509,"about_ca_system_score_gemma":0.0004096079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009538421,"about_ca_topic_score_gemma":0.001855989,"domain_scores_codex":[0.999637,0.00005359812,0.00003684865,0.0000841204,0.0001235622,0.00006484198],"domain_scores_gemma":[0.999737,0.00003077267,0.00007798219,0.00003737283,0.00002518538,0.000091845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000727445,0.000007500868,0.0004782529,0.00002989186,0.000003626325,0.00006310755,0.00001164961,0.00005118395,0.9988025,0.00004337327,0.00001312845,0.0004230427],"study_design_scores_gemma":[0.00001649426,0.0001557885,0.01473317,0.0000141571,0.00004487519,0.0006337127,0.0001145664,0.002455739,0.9789929,0.000125513,0.002695471,0.00001761438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937431,0.002072052,0.002627997,0.0001342768,0.00002836278,0.00001026015,0.0002005059,0.0001836742,0.0009997634],"genre_scores_gemma":[0.9971041,0.0003615979,0.001185833,0.00003932249,0.000005725075,0.000007912071,0.0001921977,0.00002236079,0.001080945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009538421,"threshold_uncertainty_score":0.003058255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047523235773127,"score_gpt":0.2611939155994771,"score_spread":0.2507186832417458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}