{"id":"W4409462177","doi":"10.1093/bjs/znaf061","title":"Metachronous colorectal cancer risks after extended or segmental resection in <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database","year":2025,"lang":"en","type":"article","venue":"British journal of surgery","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stanford Cancer Institute; European Regional Development Fund; Relander Foundation; Centro de Investigación Biomédica en Red de Cáncer; Universitätsklinikum Köln; Instituto de Salud Carlos III; Syöpäsäätiö; Rheinische Friedrich-Wilhelms-Universität Bonn; Universitetet i Oslo; Maag Lever Darm Stichting; Universitair Medisch Centrum Groningen; Università degli Studi di Parma; Jane ja Aatos Erkon Säätiö; Jyväskylän Yliopisto; KWF Kankerbestrijding; Humanitas Research Hospital; Deutsche Krebshilfe; University of Toronto; Consejo Nacional de Investigaciones Científicas y Técnicas; Academy of Finland; Central Manchester University Hospitals NHS Foundation Trust; Cancer Australia; Tays; Technische Universität Dresden; Deutschen Konsortium für Translationale Krebsforschung; Generalitat de Catalunya; National Institute for Health and Care Research; Centres de Recerca de Catalunya; Karolinska Institutet; Etelä-Savon Rahasto; Parc Geneteg Cymru; Health and Care Research Wales; Sigrid Juséliuksen Säätiö; Deutsches Krebsforschungszentrum; Ministerio de Economía y Competitividad; Rijksuniversiteit Groningen; Cardiff University; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Victorian Cancer Agency; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Melbourne; Ministerio de Ciencia e Innovación; Helsingin Yliopisto","keywords":"Lynch syndrome; Medicine; MSH6; MLH1; Prospective cohort study; Colorectal cancer; Internal medicine; Database; Oncology; Cancer; Surgery; DNA mismatch repair","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003801439,0.0002315115,0.0004183436,0.0004499496,0.000183096,0.0003984761,0.0002848776,0.0004218442,0.00150535],"category_scores_gemma":[0.002012905,0.0002814807,0.0008556723,0.0006764827,0.0001601978,0.0003115073,0.0004971621,0.0004747531,0.0001361151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060616,"about_ca_system_score_gemma":0.0001671359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005580418,"about_ca_topic_score_gemma":0.008558492,"domain_scores_codex":[0.9995623,0.0001208794,0.00005146782,0.0001357517,0.00005842205,0.00007117924],"domain_scores_gemma":[0.9984646,0.0003455381,0.0007231207,0.000166159,0.00007340299,0.000227204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001832119,0.00002351497,0.9953747,0.00003164203,0.0003535589,0.0001198253,0.00004299034,0.00008253982,0.0005285603,0.00001446847,0.00009523772,0.00150084],"study_design_scores_gemma":[0.00003528978,0.0001472258,0.9991772,0.000005850129,0.0001162693,0.0002091434,0.00003647621,0.00008632744,0.00005700229,0.00001139096,0.0001140332,0.00000384752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988243,0.0005244548,0.00003570265,0.00001694212,0.00000413062,0.000002846395,0.0004581718,0.000001821232,0.0001315486],"genre_scores_gemma":[0.9990854,0.000137745,0.00003471987,0.00001324572,0.000007561255,0.000003378798,0.0006260146,0.000001699775,0.00009029651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005580418,"threshold_uncertainty_score":0.01109588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02865256318606152,"score_gpt":0.3096013942375466,"score_spread":0.280948831051485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}