{"id":"W4409462177","doi":"10.1093/bjs/znaf061","title":"Metachronous colorectal cancer risks after extended or segmental resection in <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database","year":2025,"lang":"en","type":"article","venue":"British journal of surgery","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stanford Cancer Institute; European Regional Development Fund; Relander Foundation; Centro de Investigación Biomédica en Red de Cáncer; Universitätsklinikum Köln; Instituto de Salud Carlos III; Syöpäsäätiö; Rheinische Friedrich-Wilhelms-Universität Bonn; Universitetet i Oslo; Maag Lever Darm Stichting; Universitair Medisch Centrum Groningen; Università degli Studi di Parma; Jane ja Aatos Erkon Säätiö; Jyväskylän Yliopisto; KWF Kankerbestrijding; Humanitas Research Hospital; Deutsche Krebshilfe; University of Toronto; Consejo Nacional de Investigaciones Científicas y Técnicas; Academy of Finland; Central Manchester University Hospitals NHS Foundation Trust; Cancer Australia; Tays; Technische Universität Dresden; Deutschen Konsortium für Translationale Krebsforschung; Generalitat de Catalunya; National Institute for Health and Care Research; Centres de Recerca de Catalunya; Karolinska Institutet; Etelä-Savon Rahasto; Parc Geneteg Cymru; Health and Care Research Wales; Sigrid Juséliuksen Säätiö; Deutsches Krebsforschungszentrum; Ministerio de Economía y Competitividad; Rijksuniversiteit Groningen; Cardiff University; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Victorian Cancer Agency; Fundação de Amparo à Pesquisa do Estado de São Paulo; University of Melbourne; Ministerio de Ciencia e Innovación; Helsingin Yliopisto","keywords":"Lynch syndrome; Medicine; MSH6; MLH1; Prospective cohort study; Colorectal cancer; Internal medicine; Database; Oncology; Cancer; Surgery; DNA mismatch repair","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001305044,0.0003764081,0.001158009,0.000320979,0.0002049433,0.0001799952,0.0002282968,0.0001726344,0.0004866768],"category_scores_gemma":[0.0007195562,0.000309075,0.0002451769,0.0008831972,0.0002556946,0.0004084129,0.0002301992,0.001129153,0.000003944411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008567045,"about_ca_system_score_gemma":0.0009475348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006279755,"about_ca_topic_score_gemma":0.01164092,"domain_scores_codex":[0.9962912,0.0004940572,0.00117696,0.0006308052,0.0008504776,0.0005565581],"domain_scores_gemma":[0.9974075,0.001240378,0.0004512593,0.0003116284,0.000356311,0.000232923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007882603,0.001756508,0.9488696,0.0001459014,0.001057135,0.02024367,0.0007992978,0.00001970228,0.00170735,2.412864e-7,0.003805854,0.01371209],"study_design_scores_gemma":[0.005016866,0.0007586202,0.9725905,0.00261775,0.0007124868,0.01348076,0.002591563,0.00004818765,0.001721204,0.00002433993,0.0001418833,0.0002958595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763412,0.0193629,0.00001821089,0.0003033622,0.001874587,0.001652181,0.0003673364,0.00002795645,0.00005220389],"genre_scores_gemma":[0.9948844,0.003741038,0.000240315,0.0004428453,0.0001953421,0.0002719204,0.00002145329,0.00005369028,0.0001490211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02372084,"threshold_uncertainty_score":0.9999362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02865256318606152,"score_gpt":0.3096013942375466,"score_spread":0.280948831051485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}