{"id":"W4409476142","doi":"10.1007/s13555-025-01395-1","title":"Complete/Near-Complete Itch Response Observed in Patients with Moderate-to-Severe Atopic Dermatitis Initiating Dupilumab: 3-Year, Real-World, Interim Data from the PROSE Registry","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lynde Centre for Dermatology; University of Toronto","funders":"Regeneron Pharmaceuticals; Sanofi","keywords":"Dupilumab; Atopic dermatitis; Interim; Dermatology; Medicine; Interim analysis; Clinical trial; Internal medicine; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004186406,0.00025765,0.0007658628,0.000567643,0.0004169746,0.001196267,0.0003681463,0.0004910163,0.0009315863],"category_scores_gemma":[0.006291309,0.0002355631,0.001253594,0.0007384539,0.0002765199,0.001033938,0.0006551713,0.001020755,0.000265267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000341461,"about_ca_system_score_gemma":0.0004422602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001333602,"about_ca_topic_score_gemma":0.001557199,"domain_scores_codex":[0.9971675,0.001080115,0.0004610393,0.0004610169,0.0005289117,0.0003015455],"domain_scores_gemma":[0.9922578,0.001733905,0.003985004,0.0007043878,0.000787713,0.0005313082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002500956,0.0001446307,0.9918412,0.00005953955,0.0002725835,0.0001357573,0.00009755527,0.0001892035,0.0002129726,0.00003060304,0.0004100084,0.004104969],"study_design_scores_gemma":[0.0001742168,0.001133697,0.9960562,0.00002334309,0.0002244711,0.0006643081,0.0001418569,0.0004833078,0.0001712634,0.00003333415,0.0008742936,0.0000196923],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961653,0.0005694836,0.0001553407,0.00003832845,0.000009488061,0.00004564074,0.002352588,0.00001002653,0.000653862],"genre_scores_gemma":[0.9960485,0.0001539804,0.000128005,0.00004985176,0.00001814444,0.00005204821,0.003434655,0.000003246728,0.000111643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004186406,"threshold_uncertainty_score":0.02214009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05460224207085992,"score_gpt":0.3047415583324011,"score_spread":0.2501393162615412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}