{"id":"W4409483954","doi":"10.14309/crj.0000000000001673","title":"Upadacitinib Monotherapy After Tofacitinib Failure Was Successful for Induction But Not Maintenance of Remission in Medically Refractory Ulcerative Colitis","year":2025,"lang":"en","type":"article","venue":"ACG Case Reports Journal","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Tofacitinib; Medicine; Ulcerative colitis; Refractory (planetary science); Maintenance therapy; Internal medicine; Rescue therapy; Gastroenterology; Chemotherapy; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003266425,0.0004173257,0.0006928906,0.0004440905,0.001092241,0.0007586234,0.000344308,0.001453372,0.000877047],"category_scores_gemma":[0.001751187,0.0001536916,0.0006995761,0.0003191439,0.0006371387,0.0005609256,0.0003087037,0.001523527,0.0003798194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004769989,"about_ca_system_score_gemma":0.0004138813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000638177,"about_ca_topic_score_gemma":0.001449158,"domain_scores_codex":[0.9996818,0.00005640896,0.00003903971,0.00004134453,0.00004781846,0.0001335],"domain_scores_gemma":[0.998985,0.000336921,0.0002024246,0.0001400633,0.00004509223,0.0002903625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.000991223,0.0003971739,0.04852797,0.000180309,0.00009319784,0.8853348,0.0004430893,0.0004295111,0.01360285,0.0004847134,0.001381468,0.0481336],"study_design_scores_gemma":[0.0001535886,0.002365292,0.04524467,0.0000889421,0.0001140003,0.9377564,0.0002542489,0.0009501182,0.007999691,0.000281257,0.004752696,0.00003912883],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828136,0.003960956,0.002123508,0.001775928,0.0001996492,0.0001179297,0.00008188823,0.0001937417,0.008732828],"genre_scores_gemma":[0.9984661,0.0003912102,0.0002935449,0.0002421717,0.00009840676,0.00001196245,0.00005453503,0.00001437094,0.0004276169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001453372,"threshold_uncertainty_score":0.003460884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007459103185757716,"score_gpt":0.2727040120792711,"score_spread":0.2652449088935134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}