{"id":"W4409484397","doi":"10.1021/acs.jmedchem.5c00678","title":"The Prosperity and Adversity of M<sub>4</sub> Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders","year":2025,"lang":"en","type":"review","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Health and Medical Research Council; Australian Research Council","keywords":"Muscarinic acetylcholine receptor; Chemistry; Prosperity; Acetylcholine; Muscarinic acetylcholine receptor M3; Acetylcholine receptor; Neuroscience; Muscarinic acetylcholine receptor M4; Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M5; Pharmacology; Receptor; Psychology; Biochemistry; Political science; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004462099,0.0005741253,0.0007616814,0.001380103,0.0002052136,0.0006012371,0.0005864995,0.0006590585,0.003016149],"category_scores_gemma":[0.000450611,0.0002135373,0.000361457,0.001246594,0.000374846,0.0009249424,0.000459517,0.001802037,0.001791435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003969496,"about_ca_system_score_gemma":0.0006372532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006051683,"about_ca_topic_score_gemma":0.001716615,"domain_scores_codex":[0.9998846,0.00002162191,0.00001322075,0.00002189448,0.00004308281,0.00001556566],"domain_scores_gemma":[0.9998399,0.00006754424,0.00002469512,0.000005981574,0.00003883099,0.00002306546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001373664,0.00009676238,0.0001138213,0.009145967,0.00007709825,0.0001708791,0.00004982173,0.000412438,0.00362216,0.004892561,0.02797441,0.9533067],"study_design_scores_gemma":[0.00004076101,0.000256996,0.001074507,0.00175385,0.00009336136,0.001116428,0.00004816549,0.0001547136,0.0009719672,0.001882155,0.9925877,0.00001938734],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003677706,0.9973183,0.0001687515,0.0003555474,0.0002319268,0.000005093003,0.00002262885,0.00001450444,0.001515415],"genre_scores_gemma":[0.001490361,0.9968525,0.000215499,0.0003359604,0.0001975956,0.000005400534,0.00002825546,0.000002106385,0.0008723821],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003016149,"threshold_uncertainty_score":0.01008999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008315775950148015,"score_gpt":0.2715633212527523,"score_spread":0.2632475453026043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}