{"id":"W4409485298","doi":"10.1001/jamanetworkopen.2025.5331","title":"Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology","year":2025,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Izaak Walton Killam Health Centre; Montreal Neurological Institute and Hospital; Dalhousie University; University of Toronto; Nova Scotia Health Authority; Centre for Addiction and Mental Health; Saint John Regional Hospital","funders":"National Institute of Mental Health; Instituto de Salud Carlos III; Canadian Institutes of Health Research; HORIZON EUROPE Framework Programme; Genome Atlantic; National Health and Medical Research Council; Dalhousie University; Canada Research Chairs; National Institutes of Health; Generalitat de Catalunya; Dalhousie Medical Research Foundation; Fundación Alicia Koplowitz; European Regional Development Fund; European Commission; Genome Canada; Centres de Recerca de Catalunya","keywords":"Psychopathology; Bipolar disorder; Psychology; Anxiety; Mood; Major depressive disorder; Psychiatry; Mood disorders; Context (archaeology); Clinical psychology; Panic disorder; Neuroticism; Anxiety disorder; Generalized anxiety disorder; Personality","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011335,0.0003514766,0.0002320441,0.0008808769,0.0003753652,0.0005786493,0.0002730599,0.0003852399,0.001609998],"category_scores_gemma":[0.004430605,0.0002068589,0.0005444158,0.00103819,0.0004816068,0.0004169161,0.0005583256,0.0005700657,0.0001057583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001971015,"about_ca_system_score_gemma":0.0003316718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00608053,"about_ca_topic_score_gemma":0.009361916,"domain_scores_codex":[0.9991966,0.0003665555,0.00004405473,0.0002030569,0.00008493116,0.0001048283],"domain_scores_gemma":[0.9965748,0.001089019,0.001417097,0.0003553035,0.0001209248,0.0004429659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007749078,0.000006031619,0.9986101,0.0000026037,0.00007406707,0.00007244776,0.00003221743,0.00007094805,0.0001435971,0.0000285993,0.00002475075,0.0008571128],"study_design_scores_gemma":[0.000001760136,0.00003905165,0.9992954,0.00000223256,0.00003128109,0.0001810993,0.00002906983,0.0002896925,0.00002450046,0.00005964987,0.00004452546,0.000001749262],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985967,0.0002584739,0.0004570716,0.00004830988,0.000004740773,0.000005412125,0.0002647369,0.000006576967,0.0003579599],"genre_scores_gemma":[0.9995381,0.00004061688,0.0001413916,0.000005193063,0.000005742466,0.000002748117,0.0001834151,0.000001900953,0.00008106123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00608053,"threshold_uncertainty_score":0.01209027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01828791498230378,"score_gpt":0.2859391143545556,"score_spread":0.2676511993722518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}