{"id":"W4409486874","doi":"10.1016/j.jacbts.2025.02.004","title":"Fibroblast-Restricted Inflammasome Activation Promotes Atrial Fibrillation and Heart Failure With Diastolic Dysfunction","year":2025,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université du Québec à Montréal","funders":"National Heart, Lung, and Blood Institute; American Heart Association","keywords":"Inflammasome; Heart failure; Medicine; Atrial fibrillation; Internal medicine; Cardiology; Fibrosis; Cardiomyopathy; Cardiac fibrosis; Fibroblast; Diastole; Context (archaeology); Pyrin domain; Inflammation; Chemistry; Biology; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572796,0.000108231,0.0001523701,0.0002870645,0.0002432563,0.00006810851,0.00004492456,0.0000526522,0.000021745],"category_scores_gemma":[0.00008780718,0.0000899771,0.0000862727,0.001356644,0.0001223665,0.0004342019,0.00001536693,0.00008741733,0.000006105581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003943653,"about_ca_system_score_gemma":0.0003927161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002112675,"about_ca_topic_score_gemma":0.00001099969,"domain_scores_codex":[0.9988146,0.00002672986,0.0001457453,0.0003526208,0.0004898966,0.000170384],"domain_scores_gemma":[0.999458,0.00007629194,0.00002928196,0.0001584985,0.0001318928,0.000146056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00231216,0.00006750193,0.3785721,0.0002374214,0.0002963516,0.000005088312,0.0005280508,0.01218514,0.5283803,0.00416964,0.0003270326,0.07291914],"study_design_scores_gemma":[0.001230274,0.0001106362,0.9853886,0.0002086396,0.00009707049,0.00001584222,0.00001382973,0.001014278,0.009287946,0.0001568306,0.002376677,0.00009932746],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983142,0.00005109633,0.008110346,0.007682055,0.00003825477,0.0006823803,0.000006796748,0.00005715384,0.0002299628],"genre_scores_gemma":[0.9966443,0.000001862849,0.002892565,0.0001476649,0.0002104293,0.000006398896,0.00002628938,0.000005480812,0.00006500331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6068165,"threshold_uncertainty_score":0.3669159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006563606920214577,"score_gpt":0.235982105117076,"score_spread":0.2294184981968615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}