{"id":"W4409490641","doi":"10.1016/s0140-6736(25)00001-7","title":"Efficacy and safety of topical delgocitinib cream versus oral alitretinoin capsules in adults with severe chronic hand eczema (DELTA FORCE): a 24-week, randomised, head-to-head, phase 3 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Contact Dermatitis and Allergies","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lynde Centre for Dermatology","funders":"LEO Pharma","keywords":"Medicine; Head (geology); Dermatology; Randomized controlled trial; Hand eczema; Surgery; Contact dermatitis; Allergy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000272421,0.0001753005,0.0008297368,0.00006876904,0.00007601034,0.00002813178,0.0001406624,0.00007420639,0.00008839114],"category_scores_gemma":[0.0002461525,0.0001085071,0.00006984452,0.0001796296,0.0001398771,0.00004269557,0.00006208826,0.0002212049,0.000002065248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006482853,"about_ca_system_score_gemma":0.0001675176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005637861,"about_ca_topic_score_gemma":0.004512095,"domain_scores_codex":[0.9987798,0.0001194161,0.0004002518,0.0002303264,0.0001800879,0.0002900861],"domain_scores_gemma":[0.9990322,0.0003808338,0.00008097949,0.0003768002,0.00004849163,0.00008071552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9731261,0.0004430318,0.0007231461,0.000349583,0.0001902356,0.00005350019,0.001867683,0.00002778366,0.0004793005,0.0006601524,0.002925719,0.01915379],"study_design_scores_gemma":[0.9655664,0.003967389,0.01856852,0.00183693,0.0001550766,0.00002856862,0.0004146038,0.0005488048,0.0009533886,0.00006693812,0.007726248,0.0001671383],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904153,0.0006512121,0.0001034548,0.004490545,0.0002030089,0.001589292,0.00005507999,0.00002466983,0.002467431],"genre_scores_gemma":[0.9980963,0.000243781,0.0001991432,0.0003974318,0.0003894563,0.00006094237,0.00004366201,0.00001139412,0.0005578205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01898665,"threshold_uncertainty_score":0.442479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02912809264976407,"score_gpt":0.3189694904366215,"score_spread":0.2898413977868574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}