{"id":"W4409490641","doi":"10.1016/s0140-6736(25)00001-7","title":"Efficacy and safety of topical delgocitinib cream versus oral alitretinoin capsules in adults with severe chronic hand eczema (DELTA FORCE): a 24-week, randomised, head-to-head, phase 3 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Contact Dermatitis and Allergies","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lynde Centre for Dermatology","funders":"LEO Pharma","keywords":"Medicine; Head (geology); Dermatology; Randomized controlled trial; Hand eczema; Surgery; Contact dermatitis; Allergy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001303488,0.001622928,0.002988956,0.0002935726,0.0004043753,0.001148707,0.0008815452,0.001999144,0.006818638],"category_scores_gemma":[0.001426523,0.0006665308,0.002414855,0.0002799757,0.0009866524,0.001124257,0.0003428547,0.003392889,0.00124619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009016598,"about_ca_system_score_gemma":0.0007523405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001926313,"about_ca_topic_score_gemma":0.004291326,"domain_scores_codex":[0.9995728,0.0001696433,0.00002332205,0.00009757687,0.00003285194,0.0001036741],"domain_scores_gemma":[0.9993024,0.0002310177,0.000152136,0.00004466991,0.00004581968,0.0002239075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9760701,0.002607674,0.0004907068,0.0007940938,0.001145438,0.00005106075,0.00007057137,0.0002491058,0.002469346,0.00007281842,0.0009006572,0.01507853],"study_design_scores_gemma":[0.9536594,0.04281149,0.001894943,0.00004564745,0.0005018209,0.00004508355,0.00003865999,0.0001896628,0.0002496852,0.0001072956,0.0004406617,0.00001564896],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846176,0.009168632,0.0003688546,0.0008946284,0.000567494,0.001394279,0.0009384454,0.00009788818,0.001952236],"genre_scores_gemma":[0.9885527,0.003512539,0.0006241624,0.001211371,0.0003291152,0.001235172,0.0007326104,0.00002281248,0.003779501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006818638,"threshold_uncertainty_score":0.02281064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02912809264976407,"score_gpt":0.3189694904366215,"score_spread":0.2898413977868574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}