{"id":"W4409504657","doi":"10.1002/cpdd.1534","title":"A Phase 1C, Open Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of DM199 Administered Intravenously with a Polyvinyl Chloride Bag in Adult Healthy Subjects and Adults Recently Taking Angiotensin‐Converting Enzyme Inhibitors","year":2025,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Tolerability; Medicine; Pharmacokinetics; Adverse effect; Dosing; Context (archaeology); Anesthesia; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003735752,0.0003787894,0.001137897,0.0003547693,0.0002046953,0.00004489377,0.0003078496,0.0001183506,0.0000307479],"category_scores_gemma":[0.0008486823,0.0002990244,0.0000449313,0.0008500064,0.0002986923,0.0001199774,0.0007077724,0.0005732475,0.000001783146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003017512,"about_ca_system_score_gemma":0.0009414412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005310326,"about_ca_topic_score_gemma":0.002398991,"domain_scores_codex":[0.9952303,0.0006787506,0.002238283,0.0009095737,0.0003394333,0.000603701],"domain_scores_gemma":[0.9972284,0.001430498,0.0004529266,0.0002732003,0.0002887911,0.000326215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05623127,0.02003417,0.6538818,0.0005851344,0.0006946517,0.0003473383,0.04211775,0.0000415736,0.004435994,0.00002210529,0.0008107312,0.2207975],"study_design_scores_gemma":[0.1491501,0.00940665,0.765847,0.003753628,0.0007676435,0.00007561907,0.007405452,0.003642295,0.05737421,0.00005957919,0.001607502,0.0009102746],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836317,0.0005939951,0.0000121037,0.01043096,0.0008678075,0.00435715,0.000006184138,0.00003143335,0.00006867851],"genre_scores_gemma":[0.9921522,0.000233035,0.001095558,0.006144169,0.0001421945,0.0001320977,0.00001513457,0.00003181994,0.00005383704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2198872,"threshold_uncertainty_score":0.9999462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06909627066100327,"score_gpt":0.4269343132692811,"score_spread":0.3578380426082778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}