{"id":"W4409504657","doi":"10.1002/cpdd.1534","title":"A Phase 1C, Open Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of DM199 Administered Intravenously with a Polyvinyl Chloride Bag in Adult Healthy Subjects and Adults Recently Taking Angiotensin‐Converting Enzyme Inhibitors","year":2025,"lang":"en","type":"article","venue":"Clinical Pharmacology in Drug Development","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Tolerability; Medicine; Pharmacokinetics; Adverse effect; Dosing; Context (archaeology); Anesthesia; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009307842,0.001003889,0.001314422,0.000317804,0.0003633687,0.0004562254,0.0004649486,0.0008224314,0.002017763],"category_scores_gemma":[0.0007781016,0.0004141759,0.000535935,0.0002155452,0.00054313,0.0005771333,0.0001874529,0.001552144,0.0003886955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003613853,"about_ca_system_score_gemma":0.0007277989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005401418,"about_ca_topic_score_gemma":0.001266525,"domain_scores_codex":[0.9996977,0.0001353823,0.00001836912,0.00005739258,0.00004929765,0.00004185709],"domain_scores_gemma":[0.9995338,0.0001073415,0.0001108153,0.00003924104,0.00004372247,0.0001651209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5940256,0.1471613,0.007715398,0.0007042124,0.0009903762,0.0003903317,0.0003836712,0.0009707535,0.1592505,0.0002300641,0.001551117,0.08662672],"study_design_scores_gemma":[0.1553496,0.822594,0.01372631,0.00001147843,0.0002262173,0.0001715285,0.00004296907,0.0006225861,0.005838337,0.00006987998,0.001325918,0.00002107058],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965267,0.0005640771,0.0006466988,0.00009086326,0.00003433927,0.001331339,0.0002729377,0.00002971246,0.0005034263],"genre_scores_gemma":[0.992778,0.0008804533,0.001849282,0.00047378,0.0001261815,0.001641606,0.000575572,0.00001408674,0.001661072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002017763,"threshold_uncertainty_score":0.006750107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06909627066100327,"score_gpt":0.4269343132692811,"score_spread":0.3578380426082778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}