{"id":"W4409504763","doi":"10.1128/msphere.00940-24","title":"Meningococcal vaccine 4CMenB elicits a robust cellular immune response that targets but is not consistently protective against <i>Neisseria gonorrhoeae</i> during murine vaginal infection","year":2025,"lang":"en","type":"article","venue":"mSphere","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Neisseria gonorrhoeae; Immunology; Immune system; Gonorrhea; Biology; Humoral immunity; Vaccination; Pathogen; Acquired immune system; Cellular immunity; Virology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000446797,0.0004531728,0.0005816655,0.0002160664,0.0007493499,0.00008441463,0.0001980403,0.0004409369,0.001405726],"category_scores_gemma":[0.0001324633,0.0004286734,0.0002274385,0.0004741305,0.00007343786,0.000245061,0.0002336211,0.0006021591,0.0002901879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001940302,"about_ca_system_score_gemma":0.0001277318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104089,"about_ca_topic_score_gemma":0.0001793003,"domain_scores_codex":[0.9976689,0.0005403097,0.0005446642,0.0006346539,0.00002104076,0.0005904581],"domain_scores_gemma":[0.9988444,0.0001291957,0.0002421769,0.0005180177,0.0002202184,0.00004593566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004807653,0.0002430742,0.006648487,0.00009477904,0.0004839189,0.000005042783,0.0002411815,0.00006423377,0.9845996,0.00004339794,0.001073029,0.00169559],"study_design_scores_gemma":[0.004228993,0.0002863306,0.1130314,0.0001917131,0.0001243023,0.00008519304,0.0002343058,0.00002255682,0.8352125,0.00003009522,0.04613254,0.0004200645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929243,0.00178162,0.0005879924,0.0008613092,0.001748136,0.0009226573,0.00006001447,0.0002957782,0.0008182285],"genre_scores_gemma":[0.9908968,0.0001487078,0.00007247966,0.0002065981,0.00009731328,0.0002642196,0.00008764939,0.00004260272,0.008183609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1493871,"threshold_uncertainty_score":0.9998165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169618688540311,"score_gpt":0.2276868207102744,"score_spread":0.2159906338248712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}