{"id":"W4409510083","doi":"10.1007/s10875-025-01878-y","title":"Safety and Diagnostic Utility of Brain Biopsy and Metagenomics in Decision-Making for Patients with Inborn Errors of Immunity (IEI) and Unexplained Neurological Manifestations","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Brain Tumour Charity; Great Ormond Street Institute of Child Health; University College London Hospitals NHS Foundation Trust; National Institute for Health and Care Research; Cancer Research UK","keywords":"Brain biopsy; Medicine; Biopsy; Etiology; Brain tissue; Pathology; Intensive care medicine; Radiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.00185729,0.0001679043,0.0009635992,0.0002743264,0.0001300923,0.000006411052,0.0002264599,0.0003373168,0.00001727551],"category_scores_gemma":[0.01064475,0.0001266546,0.0001160876,0.0002066421,0.001358466,0.0001108606,0.0001881531,0.0006306529,2.309635e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007231206,"about_ca_system_score_gemma":0.0001286578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002602636,"about_ca_topic_score_gemma":0.00001424705,"domain_scores_codex":[0.9970133,0.0006597964,0.001843204,0.0002198418,0.00003966982,0.0002241376],"domain_scores_gemma":[0.9832046,0.01535545,0.0009541879,0.0002100779,0.0002657984,0.000009907617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01937788,0.002093275,0.7975335,0.0001115465,0.0009567249,0.00001351766,0.0007490235,0.00003621971,0.002661039,0.002420064,0.00001735697,0.1740298],"study_design_scores_gemma":[0.006945567,0.001940938,0.9866698,0.0001878789,0.0001578899,0.00004872767,0.0005217542,0.00005310266,0.00006295648,0.002828363,0.0004833113,0.00009970499],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864402,0.01084633,0.001529429,0.0004316857,0.000365198,0.000306634,0.00004113305,0.000004044371,0.00003538978],"genre_scores_gemma":[0.9977152,0.00140156,0.0007406097,0.0001091938,0.000001488237,0.000003637606,0.00001117857,0.000007044179,0.00001011425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1891363,"threshold_uncertainty_score":0.997689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533957618214225,"score_gpt":0.321374591136836,"score_spread":0.3060350149546938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}