{"id":"W4409525813","doi":"10.3390/metabo15040277","title":"Metabolic Effects of the Cancer Metastasis Modulator MEMO1","year":2025,"lang":"en","type":"article","venue":"Metabolites","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Citric acid cycle; Cell cycle; Cancer cell; Tricarboxylic acid; Gene knockdown; Cancer; Chemistry; Small hairpin RNA; Biology; Biochemistry; Cancer research; Metabolism; Cell biology; Cell; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007396351,0.0002788845,0.0001726285,0.0001700563,0.0001804342,0.0002026248,0.0001578718,0.0002117696,0.001365138],"category_scores_gemma":[0.000109162,0.00007493093,0.0001623548,0.0001181871,0.000127123,0.0001318818,0.0001828266,0.000401758,0.0002665523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002642411,"about_ca_system_score_gemma":0.0001669142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005881349,"about_ca_topic_score_gemma":0.001011752,"domain_scores_codex":[0.9999493,0.000004490432,0.000003103811,0.00001264434,0.00001755008,0.00001293766],"domain_scores_gemma":[0.9999434,0.000008334731,0.00001587315,0.000003626232,0.0000114187,0.00001731913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002526271,0.00003397718,0.0006696085,0.0001149145,0.000008275957,0.0000832504,0.000008945039,0.00009760015,0.9944481,0.00009289202,0.0003070655,0.003882748],"study_design_scores_gemma":[0.0000306491,0.0003328306,0.006432586,0.00001645652,0.00003742872,0.0003204953,0.0000362821,0.0008980974,0.9827602,0.00007037193,0.009058654,0.000005973929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805096,0.0117192,0.002332628,0.0005282004,0.0001263393,0.00003674204,0.001494164,0.0001966893,0.003056278],"genre_scores_gemma":[0.9891851,0.004095747,0.001804438,0.0002276923,0.00002390055,0.0000436075,0.001737802,0.00003326617,0.00284843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365138,"threshold_uncertainty_score":0.004566789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004833550693882624,"score_gpt":0.2494426883519825,"score_spread":0.2446091376580999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}