{"id":"W4409525813","doi":"10.3390/metabo15040277","title":"Metabolic Effects of the Cancer Metastasis Modulator MEMO1","year":2025,"lang":"en","type":"article","venue":"Metabolites","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Citric acid cycle; Cell cycle; Cancer cell; Tricarboxylic acid; Gene knockdown; Cancer; Chemistry; Small hairpin RNA; Biology; Biochemistry; Cancer research; Metabolism; Cell biology; Cell; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002368257,0.0002487375,0.0004734602,0.0000968785,0.0001078283,0.00002336938,0.0005397353,0.0001296456,0.00003211421],"category_scores_gemma":[0.0003203377,0.0001733692,0.0003949846,0.0004954764,0.0001614703,0.000006711961,0.0002761932,0.0001138472,0.000002675475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007519135,"about_ca_system_score_gemma":0.0002200492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000221502,"about_ca_topic_score_gemma":0.00007918219,"domain_scores_codex":[0.9985296,0.0001696081,0.0003207042,0.0004327197,0.000214522,0.0003329093],"domain_scores_gemma":[0.9987103,0.000037534,0.0001465092,0.0008760292,0.0001605547,0.00006906985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003539271,0.0000717974,0.002705508,0.0001215257,0.0005365039,1.20564e-7,0.00004941528,0.00005229781,0.9489096,0.004218271,0.005089177,0.0382104],"study_design_scores_gemma":[0.0004201746,0.00000760592,0.02447579,0.00001920178,0.0003602591,6.639374e-7,0.0000161802,0.000007187451,0.572844,0.0002277599,0.401519,0.0001021804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7188769,0.2747274,0.0004150248,0.0002778507,0.004255984,0.0004120927,0.00008058031,0.00001696402,0.0009372429],"genre_scores_gemma":[0.9789925,0.01216359,0.000769452,0.001158416,0.001199769,0.0002094544,0.00001596129,0.00003508541,0.00545583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3964298,"threshold_uncertainty_score":0.706979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004833550693882624,"score_gpt":0.2494426883519825,"score_spread":0.2446091376580999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}