{"id":"W4409530136","doi":"10.1038/s41467-025-58999-6","title":"Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Oncode Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; New York Stem Cell Foundation","keywords":"Colorectal cancer; Peritoneum; Medicine; Cancer research; Peritoneal carcinomatosis; Cancer; Immunology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539792,0.0001273569,0.000147367,0.0003794945,0.0001288301,0.0001882797,0.00006985051,0.000144179,0.0006347576],"category_scores_gemma":[0.000190291,0.00009453074,0.00007517412,0.0001382566,0.0001278541,0.0001542633,0.0002276273,0.0002134357,0.0001189327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007901015,"about_ca_system_score_gemma":0.00008503244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001172787,"about_ca_topic_score_gemma":0.0002824094,"domain_scores_codex":[0.9999323,0.00001812902,0.000005331707,0.00001518963,0.00001485894,0.00001414905],"domain_scores_gemma":[0.9998806,0.00002229648,0.00003895271,0.00001152827,0.00001480871,0.0000318264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001128322,0.00006592512,0.1008522,0.000125053,0.00002269697,0.0007586904,0.0001667792,0.0001231088,0.8762177,0.0001481593,0.0001391661,0.02025237],"study_design_scores_gemma":[0.0001578516,0.002259833,0.690434,0.00004595681,0.0001355509,0.0115054,0.0006696942,0.002940793,0.2848283,0.0004935437,0.006507836,0.0000211393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998021,0.001000935,0.0006086048,0.00003052032,0.000004620839,0.0000148903,0.00003715919,0.0000118111,0.0002704465],"genre_scores_gemma":[0.9987547,0.0002705867,0.0007048785,0.00002455886,0.00001123917,0.00001445725,0.00005578167,0.000001892289,0.0001619482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006347576,"threshold_uncertainty_score":0.002123475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01489519238558577,"score_gpt":0.3430940063174875,"score_spread":0.3281988139319017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}