{"id":"W4409540194","doi":"10.1016/j.ccell.2025.03.027","title":"Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation","year":2025,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Mechanisms of cancer metastasis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; University of British Columbia; University Health Network; Princess Margaret Cancer Centre","funders":"Terry Fox Research Institute; National Natural Science Foundation of China; Canada Foundation for Innovation; Canadian Institutes of Health Research; Cancer Research Society; Memorial Sloan-Kettering Cancer Center; AstraZeneca; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; U.S. Department of Defense","keywords":"Transdifferentiation; Transcription factor; Biology; Lineage (genetic); Cell biology; Genetics; Computational biology; Bioinformatics; Gene; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003646311,0.0001927459,0.0001687625,0.0000376771,0.00007283172,0.00003906858,0.000168637,0.00004305888,0.0001383533],"category_scores_gemma":[0.000009908235,0.0001711442,0.00007143262,0.0001528267,0.00001886384,0.00000900375,0.00002169709,0.00007337295,0.000002891611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005743946,"about_ca_system_score_gemma":0.0001003766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001056913,"about_ca_topic_score_gemma":0.0006150594,"domain_scores_codex":[0.9990091,0.00004098039,0.0001683601,0.0004095761,0.0001377282,0.0002342107],"domain_scores_gemma":[0.9994944,0.000005900817,0.00004476877,0.0002760161,0.00009045244,0.0000885167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008788663,0.00003912017,0.001549564,0.00007229525,0.00005692132,0.000001992813,0.00006054518,0.0009196557,0.9948936,0.00003200937,0.0004870978,0.001799303],"study_design_scores_gemma":[0.0006371263,0.0001774,0.002246006,0.00003481655,0.00008810277,9.001361e-7,0.00009009487,0.00008683979,0.9639367,0.000003942172,0.03251719,0.0001808992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9328898,0.001398015,0.06426738,0.0002539675,0.0003537268,0.0003048951,0.00005270079,0.0000242354,0.0004553481],"genre_scores_gemma":[0.9970475,0.000571335,0.0003851794,0.0005925832,0.00009327986,0.0000778808,0.0001059339,0.00002924212,0.001097063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06415777,"threshold_uncertainty_score":0.6979057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007783399116740319,"score_gpt":0.2403894139105017,"score_spread":0.2326060147937614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}