{"id":"W4409540934","doi":"10.1016/j.celbio.2025.100070","title":"Highly pathogenic avian influenza H5N1 clade 2.3.4.4b hemagglutinin and/or neuraminidase elicit immunity in a recombinant nanoparticle vaccine","year":2025,"lang":"en","type":"article","venue":"Cell Biomaterials","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Food Inspection Agency; University of Manitoba; Public Health Agency of Canada","funders":"National Institutes of Health; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Influenza A virus subtype H5N1; Neuraminidase; Virology; Hemagglutinin (influenza); Recombinant DNA; Highly pathogenic; Influenza vaccine; Immunity; H5N1 genetic structure; Biology; Microbiology; Medicine; Virus; Immunology; Immune system; Gene; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Genetics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003252876,0.000330416,0.000163204,0.0001488061,0.0001249893,0.0001876578,0.0001738437,0.0003545822,0.0008868357],"category_scores_gemma":[0.0001232021,0.0001316411,0.0002668198,0.00005183894,0.0001248183,0.0001759154,0.0001445202,0.0004106731,0.0003107165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183815,"about_ca_system_score_gemma":0.0001332103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004803593,"about_ca_topic_score_gemma":0.0007105979,"domain_scores_codex":[0.9998916,0.00002399149,0.000007046069,0.00002109051,0.00002599326,0.00003027584],"domain_scores_gemma":[0.999953,0.00001350249,0.000006117076,0.000004356785,0.00001278438,0.00001021627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005885447,0.00003897972,0.00004190532,0.000009473462,0.000002776841,0.00001010493,0.000007648496,0.00004492138,0.999337,0.00003061859,0.00001690039,0.0004007951],"study_design_scores_gemma":[0.00002442914,0.0007100817,0.0008052282,0.000003084194,0.00001584253,0.00007192125,0.00001893914,0.000833794,0.9967116,0.00003290343,0.0007702878,0.000001924863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949532,0.00037738,0.003347665,0.00006396134,0.00004126882,0.00007176158,0.00007487893,0.00001868705,0.001051047],"genre_scores_gemma":[0.9930311,0.0002527162,0.003680262,0.00007034576,0.00001073132,0.00003381512,0.000170899,0.0000100098,0.002740108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008868357,"threshold_uncertainty_score":0.002966762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05043566282775146,"score_gpt":0.3551509225988477,"score_spread":0.3047152597710963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}