{"id":"W4409546899","doi":"10.1016/j.jbc.2025.108510","title":"MitoSNO inhibits mitochondrial hydrogen peroxide generation by α-ketoglutarate dehydrogenase","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University; Ste. Anne's Hospital","funders":"Lady Davis Institute for Medical Research; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of Cambridge; McGill University","keywords":"Hydrogen peroxide; Dehydrogenase; Chemistry; Biochemistry; Pyruvate dehydrogenase complex; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000993045,0.0004138357,0.0002484368,0.0001172791,0.0000986462,0.0001651303,0.0001545482,0.0001872542,0.0005900161],"category_scores_gemma":[0.00009216987,0.0000884725,0.0001531246,0.00006835478,0.0001488172,0.0001400583,0.0001238422,0.0003494414,0.000184838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001246183,"about_ca_system_score_gemma":0.0001162104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003021608,"about_ca_topic_score_gemma":0.0006202683,"domain_scores_codex":[0.9999253,0.00001674939,0.00001020489,0.00001212574,0.00002083585,0.00001478675],"domain_scores_gemma":[0.9999323,0.00001187087,0.00002403999,0.000008362138,0.000009768539,0.00001357893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001861148,0.00003774407,0.0001652374,0.00006071577,0.000007184755,0.00004954045,0.00001093672,0.00006246294,0.9976289,0.00004579344,0.00003726743,0.001708127],"study_design_scores_gemma":[0.00002331762,0.0007045739,0.001596987,0.000004428983,0.00001576916,0.0001613073,0.000009528116,0.0004377326,0.9952094,0.00001903348,0.00181538,0.000002534936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871699,0.006250688,0.00504121,0.0001844045,0.0001003854,0.00003858563,0.0001568721,0.0001130626,0.0009449623],"genre_scores_gemma":[0.9919999,0.003836776,0.002706785,0.00006373232,0.0000311432,0.00002389434,0.0003105889,0.000009741972,0.0010175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005900161,"threshold_uncertainty_score":0.001973808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511466321705832,"score_gpt":0.2500118922017728,"score_spread":0.2348972289847145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}