{"id":"W4409548049","doi":"10.1016/j.biosx.2025.100621","title":"Paper discs in a 3D printed microplate hybrid microfluidic device for low-cost, rapid, and ultrasensitive paper-based bioluminescence detection of human epidermal growth factor receptor 2 (HER2) breast cancer biomarker","year":2025,"lang":"en","type":"article","venue":"Biosensors and Bioelectronics X","topic":"Biosensors and Analytical Detection","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Human Epidermal Growth Factor Receptor 2; Bioluminescence; Human breast; Biomarker; Epidermal growth factor receptor; Microfluidics; Breast cancer; Epidermal growth factor; Chemistry; Materials science; Cancer; Receptor; Nanotechnology; Medicine; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001430977,0.0003226886,0.0003921566,0.0002531368,0.0001225309,0.00004352128,0.00006748239,0.0001909295,0.00001717497],"category_scores_gemma":[0.00003418303,0.0002868574,0.0001038872,0.0004258052,0.0001700708,0.0001126816,0.00002075341,0.0002157779,8.423165e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001506221,"about_ca_system_score_gemma":0.00005003149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003675084,"about_ca_topic_score_gemma":0.0004570631,"domain_scores_codex":[0.9984946,0.00006022413,0.0004359866,0.0004366697,0.00008791297,0.000484633],"domain_scores_gemma":[0.999451,0.0001193951,0.00007929944,0.0001396807,0.0001191539,0.00009147299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002004917,0.00005968197,0.001041436,0.0003608921,0.00007986105,0.00000191748,0.00002179635,0.000003616991,0.9615003,0.00002745217,0.00007721593,0.0366253],"study_design_scores_gemma":[0.001134102,0.0001271713,0.03115826,0.0002293006,0.0000614217,0.00001133333,0.00003448972,0.00908363,0.9570772,0.00002796882,0.0007064189,0.000348695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949571,0.002467372,0.000961205,0.0004111707,0.0001311244,0.0005612366,0.0004192893,0.00007587889,0.00001565962],"genre_scores_gemma":[0.9966171,0.002974225,0.0001099826,0.000135227,0.00004025651,0.00003348134,0.00003192637,0.00003354936,0.000024289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0362766,"threshold_uncertainty_score":0.9999583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008096210114422147,"score_gpt":0.2318220751217844,"score_spread":0.2237258650073623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}