{"id":"W4409552586","doi":"10.21203/rs.3.rs-6017396/v1","title":"Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Precision oncology; Esophageal adenocarcinoma; Esophageal cancer; Adenocarcinoma; Oncology; Internal medicine; Medicine; Cancer research; Cancer; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006371004,0.0005034714,0.0004640102,0.0002596247,0.0002369283,0.0007718939,0.0005426728,0.0008631279,0.005702964],"category_scores_gemma":[0.0005164266,0.0003077261,0.0004368001,0.0001938483,0.0002395041,0.0002562208,0.0005577352,0.001117443,0.002937966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002237408,"about_ca_system_score_gemma":0.0004051143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005095138,"about_ca_topic_score_gemma":0.000925892,"domain_scores_codex":[0.9995927,0.00008856152,0.00001808423,0.00009963129,0.0001385958,0.00006235349],"domain_scores_gemma":[0.99983,0.00005481568,0.00001275818,0.00004742061,0.00003430301,0.00002065902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001478838,0.00007497624,0.0008660697,0.0001797534,0.00005142855,0.0001714591,0.00006177415,0.001014087,0.9783972,0.001725456,0.00496098,0.01234892],"study_design_scores_gemma":[0.00004298765,0.0003516745,0.003318704,0.00001754597,0.00009230283,0.0007731031,0.00007434658,0.005832775,0.9437935,0.0009933952,0.04467888,0.00003073088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.491668,0.008098611,0.4369183,0.003020975,0.001822766,0.0006052815,0.02101636,0.005262171,0.03158757],"genre_scores_gemma":[0.819642,0.002942794,0.1378206,0.001766217,0.0001774415,0.0006019883,0.01536994,0.0006820205,0.02099707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005702964,"threshold_uncertainty_score":0.01907831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1058531471605569,"score_gpt":0.4056643581665629,"score_spread":0.2998112110060059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}