{"id":"W4409558008","doi":"10.3390/vaccines13040420","title":"Monitoring Immune Responses to Vaccination: A Focus on Single-Cell Analysis and Associated Challenges","year":2025,"lang":"en","type":"review","venue":"Vaccines","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Immune system; Vaccination; Immunology; Preparedness; Computational biology; Computer science; Biology; Medicine; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002153554,0.001230372,0.002210588,0.002044533,0.0002937815,0.001685821,0.00151176,0.002284531,0.002792728],"category_scores_gemma":[0.00205883,0.0005029414,0.0008008945,0.00177841,0.001282497,0.002606499,0.001035335,0.003193756,0.002365362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001158552,"about_ca_system_score_gemma":0.001605347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044633,"about_ca_topic_score_gemma":0.001281177,"domain_scores_codex":[0.9994609,0.0001193997,0.00004815492,0.0001251423,0.0001921613,0.00005427851],"domain_scores_gemma":[0.9981979,0.001174024,0.0001232975,0.00005337273,0.0003645963,0.0000868537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001063914,0.00009396393,0.0003607,0.02375034,0.0001330902,0.0002031319,0.0001112515,0.001000691,0.008445588,0.01735439,0.03453845,0.913902],"study_design_scores_gemma":[0.0000108327,0.0001378974,0.0007385323,0.003628907,0.00009959552,0.0008167677,0.00009848336,0.0003041842,0.002262042,0.007006608,0.9848583,0.0000378401],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009986649,0.9978406,0.0005121595,0.0005340428,0.0002730439,0.000004729104,0.00002151059,0.00001167027,0.0007021896],"genre_scores_gemma":[0.0007569591,0.9975005,0.0004682438,0.0003797245,0.0002982269,0.00001091177,0.00003746496,0.00000419185,0.0005436849],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002792728,"threshold_uncertainty_score":0.01138926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04271796347373637,"score_gpt":0.3024435759968231,"score_spread":0.2597256125230868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}