{"id":"W4409561720","doi":"10.1016/j.ebiom.2025.105697","title":"Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adults","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"European Commission; National Health and Medical Research Council; Horizon 2020 Framework Programme; H2020 Marie Skłodowska-Curie Actions; University of Melbourne; Australian Research Council","keywords":"T-cell receptor; Immunology; Biology; CD8; Human leukocyte antigen; Epitope; Influenza A virus; Cytotoxic T cell; Immune system; Virology; T cell; Virus; Antigen; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001401168,0.0003877322,0.0009393692,0.0009235782,0.000167032,0.00002696105,0.0003732965,0.0001930665,0.0001344108],"category_scores_gemma":[0.0008276759,0.0002255376,0.00008040493,0.002429692,0.001334976,0.00007977889,0.0002098594,0.0007220957,0.00002015751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002826114,"about_ca_system_score_gemma":0.0002576313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003779844,"about_ca_topic_score_gemma":0.003544942,"domain_scores_codex":[0.9968197,0.0002246206,0.0006383769,0.0005260629,0.001050315,0.0007408647],"domain_scores_gemma":[0.9974163,0.0005734175,0.0003808217,0.0006634025,0.0007948117,0.000171281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00988029,0.004023209,0.8190436,0.002699255,0.003691136,0.001502459,0.03835261,0.00003738062,0.04199062,0.0009528197,0.05977114,0.01805544],"study_design_scores_gemma":[0.01438135,0.00112264,0.9459579,0.004453042,0.0001674701,0.000009326355,0.005449424,0.00006556095,0.01597416,0.00003907432,0.01206322,0.0003168088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784105,0.006721684,0.0000499778,0.01228734,0.000253408,0.001446614,0.00007922956,0.00007382376,0.0006774262],"genre_scores_gemma":[0.9950954,0.0006302159,0.00005099604,0.002977749,0.000184403,0.000132665,0.0000590656,0.00004073768,0.0008287823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1269143,"threshold_uncertainty_score":0.9197155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06221406974117449,"score_gpt":0.3346352628365552,"score_spread":0.2724211930953807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}