{"id":"W4409566295","doi":"10.1080/17576180.2025.2471243","title":"Recommendations on biomarker assay validation (BAV) in tissues by GCC","year":2025,"lang":"en","type":"article","venue":"Bioanalysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pharma Medica Research (Canada); Green Communities Canada; Royal Canadian Military Institute; Altasciences (Canada)","funders":"","keywords":"Biomarker; Computational biology; Chemistry; Chromatography; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1070689,0.002460002,0.001694794,0.007560106,0.003481432,0.007576722,0.007855268,0.02197056,0.01293014],"category_scores_gemma":[0.1813072,0.001700126,0.004142457,0.005831595,0.004607166,0.005292493,0.005769467,0.01009212,0.0202818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004274065,"about_ca_system_score_gemma":0.04335776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02813163,"about_ca_topic_score_gemma":0.02423514,"domain_scores_codex":[0.8973204,0.04485335,0.01387685,0.003433784,0.03548456,0.00503102],"domain_scores_gemma":[0.6247603,0.1007071,0.02129533,0.02044173,0.221958,0.01083754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002336011,0.0002029713,0.002072304,0.003091259,0.00006327748,0.0004742682,0.0009226275,0.001222418,0.005256524,0.01018701,0.8587267,0.117547],"study_design_scores_gemma":[0.00005542921,0.0001305801,0.002654998,0.005842227,0.00008412558,0.0003239443,0.0007002036,0.0004136709,0.003865922,0.006046728,0.9797757,0.0001065069],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.01060518,0.05715184,0.1261331,0.4695311,0.06005397,0.01180351,0.01960758,0.01001553,0.235098],"genre_scores_gemma":[0.02782628,0.04211245,0.4035875,0.3497294,0.007162616,0.01135743,0.02242171,0.003088273,0.1327143],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.1070689,"threshold_uncertainty_score":0.566241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02988023209794945,"score_gpt":0.3393628718606383,"score_spread":0.3094826397626889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}