{"id":"W4409572164","doi":"10.1038/s41598-024-83693-w","title":"Mendelian randomization study of sleep traits and risk of colorectal cancer","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Center for Advancing Translational Sciences; Instituto de Salud Carlos III; Cancer Council Victoria; National Health and Medical Research Council; Medical Research Council; Canadian Cancer Society Research Institute; Chonnam National University Hwasun Hospital; Centers for Disease Control and Prevention; Fred Hutchinson Cancer Research Center; Biobanco Vasco; Xunta de Galicia; Medizinische Universität Graz; Deutsche Krebshilfe; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Vetenskapsrådet; Ministerio de Economía y Competitividad; University Hospitals Bristol NHS Foundation Trust; Canadian Institutes of Health Research; Cancerfonden; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; Karl-Franzens-Universität Graz; University of Bristol; Generalitat de Catalunya; Food Standards Agency; Department of Health and Social Care; World Health Organization; Wageningen University and Research; Cancer Research UK; Johns Hopkins University; NIHR Bristol Biomedical Research Centre; Conseil Régional des Pays de la Loire; Génome Québec; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Harvard T.H. Chan School of Public Health; Mike and Josie Harper Cancer Research Institute; National Institutes of Health; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; Florida Department of Health; University of Cambridge; University of Pittsburgh; Memorial Sloan-Kettering Cancer Center; Association Anne de Bretagne Genetique; McGill University; Moffitt Cancer Center; Pelotonia; Brigham and Women's Hospital; University of South Florida; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Chronotype; Colorectal cancer; Genome-wide association study; Oncology; Medicine; Genetic association; Insomnia; Internal medicine; Cancer; Genotype; Genetics; Biology; Single-nucleotide polymorphism; Morning; Gene; Psychiatry; Genetic variants","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01000835,0.0005183205,0.0007824576,0.0007213129,0.0003123971,0.00040896,0.0005457248,0.0004604654,0.00227418],"category_scores_gemma":[0.02421872,0.0002485785,0.001119088,0.00065722,0.0005656044,0.0002524836,0.0003686151,0.0003795321,0.0001417433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474227,"about_ca_system_score_gemma":0.0003962039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001642501,"about_ca_topic_score_gemma":0.0009619274,"domain_scores_codex":[0.9855824,0.01108834,0.0005263915,0.00169479,0.0008573803,0.0002508383],"domain_scores_gemma":[0.9890215,0.005820225,0.002133058,0.002561017,0.0002790409,0.0001851453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01984248,0.0003656878,0.8783626,0.0004747889,0.01010022,0.00162128,0.000549558,0.00515796,0.0182379,0.01134146,0.002277055,0.05166896],"study_design_scores_gemma":[0.002259532,0.008597136,0.8890509,0.0001292064,0.004870818,0.004364015,0.0002788834,0.06632429,0.006354165,0.01230488,0.005336317,0.0001297893],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9512041,0.0008438326,0.04566338,0.0001698357,0.00008418797,0.0002829163,0.0007236713,0.0001721744,0.0008560549],"genre_scores_gemma":[0.9921666,0.00008874905,0.007005553,0.00005258804,0.00001475773,0.0001705198,0.0001855371,0.00001613374,0.0002996009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01000835,"threshold_uncertainty_score":0.05292982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214104606764303,"score_gpt":0.2641739429037819,"score_spread":0.2520328968361389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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