{"id":"W4409572998","doi":"10.2139/ssrn.5220090","title":"Wheat Fiber Suppresses Development of Colitis via Microbiota-Mediated Fermentation-Independent Metabolites that Reprogram Intestinal Macrophages","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Fermentation; Colitis; Fiber; Chemistry; Microbiology; Cell biology; Biology; Food science; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001772202,0.000337561,0.000288596,0.0002532105,0.0001034801,0.0002867258,0.0001395404,0.0003952876,0.002832753],"category_scores_gemma":[0.000170197,0.0001407539,0.0002369104,0.000179467,0.0002630988,0.0001862684,0.0002342249,0.0007274955,0.0004289786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001471267,"about_ca_system_score_gemma":0.0001847299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000371505,"about_ca_topic_score_gemma":0.0006607232,"domain_scores_codex":[0.9998564,0.00003732137,0.00001442808,0.00002848508,0.00002505896,0.00003834513],"domain_scores_gemma":[0.9998869,0.00001560226,0.00003147129,0.00001665548,0.00001103194,0.00003834644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001616174,0.0001161112,0.000194057,0.00004025288,0.00001188083,0.00004020627,0.00001711776,0.00005503864,0.9949185,0.0001121333,0.00006425354,0.0028142],"study_design_scores_gemma":[0.0001962551,0.002105938,0.009323115,0.00001527931,0.00005098823,0.0001210229,0.00007974605,0.0006528299,0.9839458,0.0002183674,0.003284486,0.000006197951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948435,0.000816519,0.002091369,0.0002071096,0.00007593644,0.00002055801,0.0003158751,0.00009511801,0.001534053],"genre_scores_gemma":[0.9931458,0.0006027184,0.001442273,0.0001008545,0.0000197253,0.00003142147,0.0003546846,0.00004242492,0.004260096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002832753,"threshold_uncertainty_score":0.009476483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01008868240558483,"score_gpt":0.2744268048558373,"score_spread":0.2643381224502524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}