{"id":"W4409578902","doi":"10.1038/s41408-025-01288-8","title":"Comment on: “Switching TKIs during CML therapy is frequent, mostly driven by intolerance, and does not affect survival: a prospective Quebec registry study” by Busque et al.","year":2025,"lang":"en","type":"letter","venue":"Blood Cancer Journal","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Affect (linguistics); Medicine; Prospective cohort study; Intensive care medicine; Internal medicine; Psychology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0004877633,0.001044888,0.001601586,0.0002686765,0.0004661242,0.0003473926,0.0004416256,0.000509386,0.0002295873],"category_scores_gemma":[0.00004371551,0.0007552687,0.0003371211,0.0002453469,0.0001076909,0.000187731,0.0001446094,0.005530991,0.000002760474],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004136838,"about_ca_system_score_gemma":0.001575854,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01476477,"about_ca_topic_score_gemma":0.00185384,"domain_scores_codex":[0.9952276,0.0005329394,0.0008385949,0.001215679,0.001345712,0.000839439],"domain_scores_gemma":[0.9975028,0.0002892907,0.0008636141,0.0008524951,0.0002239652,0.0002678602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007500765,0.0009773056,0.05048953,0.0003584576,0.006126796,0.001837251,0.002068223,0.000003522386,0.002709125,0.000003207573,0.9332629,0.001413626],"study_design_scores_gemma":[0.04937047,0.002228193,0.01141921,0.005857822,0.002041007,0.0006695891,0.0005398656,0.00001286057,0.01873437,0.00004072132,0.9077071,0.001378822],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3258174,0.004810181,0.00001805949,0.6652881,0.0009174789,0.002151999,0.0006680175,0.00008454816,0.0002442116],"genre_scores_gemma":[0.1216125,0.01418971,0.0001127747,0.8511717,0.002260958,0.0007662776,0.0001526588,0.0002438723,0.009489561],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2042049,"threshold_uncertainty_score":0.9996861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339595303381396,"score_gpt":0.2998396381446816,"score_spread":0.2864436851108677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}