{"id":"W4409583153","doi":"10.1001/jamanetworkopen.2025.5810","title":"Self- and Informant-Report Cognitive Decline Discordance and Mild Cognitive Impairment Diagnosis","year":2025,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; Patient-Centered Outcomes Research Institute; National Institute of Mental Health; National Institutes of Health; Larry L. Hillblom Foundation; Genentech; IXICO; Eisai; Eli Lilly and Company; U.S. Department of Defense; Australian Catholic University; Northern California Institute for Research and Education; Biogen; BioClinica; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; H. Lundbeck A/S; Bristol-Myers Squibb; Canadian Institutes of Health Research; California Department of Public Health; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Cognitive decline; Cognition; Geriatric Depression Scale; Observational study; Psychology; Depression (economics); Clinical psychology; Cohort study; Cognitive impairment; Cohort; Medicine; Gerontology; Disease; Psychiatry; Internal medicine; Depressive symptoms","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001171447,0.0002685042,0.0004838495,0.0001217544,0.000300637,0.0003929147,0.000161957,0.0001045172,0.000179843],"category_scores_gemma":[0.0002832309,0.0002240619,0.00006185686,0.0004557348,0.0002079114,0.0005043991,0.001443372,0.0003484258,0.00002468585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000520859,"about_ca_system_score_gemma":0.0002488549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001241147,"about_ca_topic_score_gemma":0.00008327704,"domain_scores_codex":[0.9979555,0.0001238786,0.0004624883,0.0005262608,0.000366466,0.0005653863],"domain_scores_gemma":[0.9983805,0.0006543314,0.0001416512,0.0001793712,0.0003615451,0.0002826282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001948632,0.0004117039,0.9486976,0.000215708,0.0006072075,0.0004332777,0.0002766497,2.796819e-7,0.000002164601,0.0001739232,0.004578061,0.04265475],"study_design_scores_gemma":[0.009324855,0.0008439433,0.9754751,0.002374761,0.0005502759,0.0001607351,0.001095242,0.0003336995,0.0003617552,0.000472329,0.008771372,0.000235947],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542655,0.001983597,0.000359584,0.004365909,0.0001165313,0.003660776,0.00003349892,0.00005566244,0.03515898],"genre_scores_gemma":[0.9850653,0.004246614,0.0007370652,0.005092844,0.0002018003,0.0009917759,0.0001780215,0.00002085909,0.003465654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0424188,"threshold_uncertainty_score":0.913698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01517934862232185,"score_gpt":0.3447314690151853,"score_spread":0.3295521203928635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}