{"id":"W4409586510","doi":"10.2147/jhc.s510460","title":"A Novel Prognostic Signature Integrating Immune and Glycolytic Pathways for Enhanced Prognosis and Immunotherapy Prediction in Hepatocellular Carcinoma","year":2025,"lang":"en","type":"article","venue":"Journal of Hepatocellular Carcinoma","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Hepatocellular carcinoma; Immunotherapy; Signature (topology); Immune system; Medicine; Glycolysis; Oncology; Cancer research; Internal medicine; Immunology; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006556235,0.0004105205,0.0004145867,0.001196025,0.0001929832,0.0005526746,0.0001971472,0.000234195,0.0007725871],"category_scores_gemma":[0.000948554,0.00009019056,0.0004120439,0.001079369,0.0002274355,0.0002727559,0.0004138008,0.000318526,0.0002007578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003310346,"about_ca_system_score_gemma":0.0004559287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00064717,"about_ca_topic_score_gemma":0.001243846,"domain_scores_codex":[0.9998173,0.00004128728,0.00001669244,0.00004278455,0.00004378137,0.00003819203],"domain_scores_gemma":[0.9995425,0.0001019898,0.0001775604,0.0000316664,0.00008785971,0.00005849772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008605488,0.00009798142,0.9182586,0.0001584186,0.0002122796,0.0002040166,0.00006555203,0.005609477,0.02320195,0.0002501337,0.0009040481,0.05017709],"study_design_scores_gemma":[0.0000493446,0.0006017769,0.9129564,0.00006524703,0.0005729652,0.0009363536,0.0002395412,0.06523135,0.01459462,0.001760585,0.002943741,0.00004819859],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909933,0.0009446339,0.005506045,0.0001537901,0.0000201427,0.00003797523,0.001498061,0.00009161473,0.0007542821],"genre_scores_gemma":[0.9958076,0.0001753697,0.002610372,0.00003107604,0.00001648888,0.00002521842,0.001162231,0.000007741829,0.0001638652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001196025,"threshold_uncertainty_score":0.003467321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717868099964072,"score_gpt":0.2402592827840579,"score_spread":0.2230806017844172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}