{"id":"W4409589963","doi":"10.1016/j.xops.2025.100798","title":"Effect of Faricimab versus Aflibercept on Hyperreflective Foci in Patients with Diabetic Macular Edema from the YOSEMITE/RHINE Trials","year":2025,"lang":"en","type":"article","venue":"Ophthalmology Science","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"European Commission; F. Hoffmann-La Roche; Roche","keywords":"Aflibercept; Diabetic macular edema; Ophthalmology; Medicine; Optometry; Diabetes mellitus; Diabetic retinopathy; Surgery; Bevacizumab; Endocrinology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002414364,0.0007057976,0.001716012,0.0002413057,0.0002272205,0.0009017848,0.0004219301,0.0007053848,0.002269636],"category_scores_gemma":[0.002138895,0.0003413369,0.002329268,0.0001969943,0.0003581133,0.0006472385,0.0002415513,0.001300901,0.0002670214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004471894,"about_ca_system_score_gemma":0.0004857835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006179237,"about_ca_topic_score_gemma":0.00219375,"domain_scores_codex":[0.9994552,0.0003254848,0.00004798585,0.00007513537,0.00004577068,0.0000504181],"domain_scores_gemma":[0.9993013,0.0002536594,0.0002211921,0.00004392007,0.00005661045,0.0001232579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.872754,0.002678995,0.005800005,0.002715864,0.005061014,0.00009732875,0.00008588118,0.001885282,0.006808082,0.0002514386,0.002201337,0.09966063],"study_design_scores_gemma":[0.860325,0.09843641,0.02681417,0.0004277354,0.004880007,0.0003173171,0.00008550213,0.00312807,0.001555278,0.0004789564,0.003494798,0.00005666111],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563942,0.03572977,0.0008049122,0.0008984272,0.0002826498,0.001301082,0.0008675147,0.00007573676,0.003645726],"genre_scores_gemma":[0.9908912,0.004768944,0.001152928,0.0008035419,0.0001520869,0.0006691857,0.0006696834,0.00001253755,0.0008799587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002414364,"threshold_uncertainty_score":0.01276851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02007339017598306,"score_gpt":0.3620887380875749,"score_spread":0.3420153479115918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}