{"id":"W4409601965","doi":"10.1016/j.jcjo.2025.02.015","title":"Toxic ethambuthol-induced optic neuropathy in a patient with OPA1 mutation","year":2025,"lang":"en","type":"letter","venue":"Canadian Journal of Ophthalmology","topic":"Drug-Induced Ocular Toxicity","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Optic neuropathy; Mutation; Medicine; Genetics; Biology; Optic nerve; Ophthalmology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005486457,0.001830062,0.001185878,0.001761213,0.00328847,0.001823203,0.001329756,0.009679066,0.003327519],"category_scores_gemma":[0.004986342,0.0007340267,0.001850152,0.00135978,0.001727519,0.001566465,0.001083007,0.004631876,0.000909409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004684031,"about_ca_system_score_gemma":0.001989973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01041134,"about_ca_topic_score_gemma":0.01212733,"domain_scores_codex":[0.9992332,0.00009692235,0.00009897791,0.0001279834,0.0001701115,0.0002727502],"domain_scores_gemma":[0.9980286,0.0008106867,0.0002503133,0.0001057273,0.0001980158,0.0006066944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00003947924,0.00001983425,0.001557626,0.00001918257,0.000005946989,0.9961411,0.00004909613,0.00005071039,0.0002432463,0.0001963683,0.001110243,0.0005671355],"study_design_scores_gemma":[0.00004149764,0.0001035469,0.005184307,0.0000424987,0.00003197277,0.9904512,0.0001230344,0.0007109826,0.000497196,0.0006361456,0.002161549,0.00001594112],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8054425,0.007762346,0.00308917,0.08090559,0.005692133,0.0004334676,0.0008616855,0.0005364771,0.09527666],"genre_scores_gemma":[0.9725443,0.00172099,0.001522032,0.0123704,0.004014588,0.00004885803,0.0001440522,0.00006465332,0.00757008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01041134,"threshold_uncertainty_score":0.0339852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409145858928605,"score_gpt":0.268748511400729,"score_spread":0.244657052811443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}