{"id":"W4409601965","doi":"10.1016/j.jcjo.2025.02.015","title":"Toxic ethambuthol-induced optic neuropathy in a patient with OPA1 mutation","year":2025,"lang":"en","type":"letter","venue":"Canadian Journal of Ophthalmology","topic":"Drug-Induced Ocular Toxicity","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Optic neuropathy; Mutation; Medicine; Genetics; Biology; Optic nerve; Ophthalmology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003942537,0.000448393,0.001133862,0.002197738,0.00007042867,0.00004353091,0.0003497178,0.001012229,0.00024792],"category_scores_gemma":[0.0007202591,0.0003989789,0.0002307214,0.0006316897,0.0001429012,0.0001104235,0.00002561746,0.004382899,0.00002133285],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001151255,"about_ca_system_score_gemma":0.008404378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003131918,"about_ca_topic_score_gemma":0.0004050403,"domain_scores_codex":[0.9968959,0.0005053437,0.0009324217,0.0004409818,0.0004275326,0.0007977911],"domain_scores_gemma":[0.997589,0.0001813255,0.0006660263,0.0005004787,0.0004853861,0.0005777773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00007894867,0.00003815275,0.001783736,0.0001896248,0.0001415839,0.9816166,0.0003886414,0.00005562973,0.0002021959,0.000006709762,0.01477924,0.0007189798],"study_design_scores_gemma":[0.001756173,0.002641743,0.008840285,0.00124184,0.0002945809,0.9752634,0.0001632545,0.00002528679,0.0006722255,0.0001004689,0.008591891,0.0004088507],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8602941,0.0002394289,0.000008586608,0.1245176,0.001281474,0.0005053093,0.00002557785,0.00000566355,0.01312222],"genre_scores_gemma":[0.939961,0.000001438809,0.0005637635,0.05766115,0.0007202658,0.00001499711,0.00006196073,0.00007987455,0.000935626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07966683,"threshold_uncertainty_score":0.9998462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409145858928605,"score_gpt":0.268748511400729,"score_spread":0.244657052811443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}