{"id":"W4409618264","doi":"10.21769/bioprotoc.5296","title":"Proteome Birthdating: A Single-Sample Approach for Measuring Global Turnover Dynamics and &amp;ldquo;Protein Age&amp;rdquo;","year":2025,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institute of General Medical Sciences; National Institute on Aging; National Institutes of Health","keywords":"Proteome; Sample (material); Dynamics (music); Protein turnover; Chemistry; Biochemistry; Chromatography; Psychology; Protein biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002165799,0.0017828,0.001121527,0.001390796,0.001240589,0.001446878,0.002483976,0.001308189,0.003883192],"category_scores_gemma":[0.001611514,0.001167435,0.0006315865,0.001239652,0.001055405,0.001977906,0.001844641,0.004308461,0.002437777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001074879,"about_ca_system_score_gemma":0.001349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007629069,"about_ca_topic_score_gemma":0.001806124,"domain_scores_codex":[0.9985567,0.0002538076,0.00009587375,0.0004328023,0.0005602941,0.0001006158],"domain_scores_gemma":[0.9988053,0.0002698039,0.0002068296,0.0003428725,0.0002599729,0.0001152927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001275467,0.00004990083,0.0001623188,0.0003200081,0.00002344611,0.00009301585,0.00008119921,0.000231746,0.972509,0.003348796,0.002091716,0.02096133],"study_design_scores_gemma":[0.00002074137,0.0001125615,0.0005180549,0.0000201466,0.00002261394,0.0002479312,0.0000191182,0.003765825,0.9559304,0.001029221,0.03825887,0.00005461685],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03464564,0.004109309,0.949297,0.0005443083,0.0005167719,0.0008186154,0.002669155,0.003595828,0.003803504],"genre_scores_gemma":[0.08628385,0.007075804,0.8811661,0.0007163251,0.0001377758,0.002906702,0.004718739,0.001520215,0.01547445],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003883192,"threshold_uncertainty_score":0.01299053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04812161100801347,"score_gpt":0.3312508432851315,"score_spread":0.283129232277118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}