{"id":"W4409624304","doi":"10.1158/1538-7445.am2025-1118","title":"Abstract 1118: The GENIE BPC BRCA Cohort: a real-world repository of standardized clinical and genomic data for young patients with breast cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Cohort; Cancer; Breast cancer; Real world data; Oncology; Internal medicine; Computer science; Data science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002660906,0.0004110454,0.0005858196,0.003077771,0.0005264871,0.001327068,0.001107161,0.0006350969,0.002844381],"category_scores_gemma":[0.008613145,0.0003626818,0.000349728,0.004277065,0.0002886805,0.0005810775,0.001597885,0.0006080704,0.001382427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001282955,"about_ca_system_score_gemma":0.002448207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03295095,"about_ca_topic_score_gemma":0.05235068,"domain_scores_codex":[0.9986073,0.0003186948,0.0001462504,0.0005091806,0.0002968872,0.0001215847],"domain_scores_gemma":[0.9925191,0.001276165,0.00192057,0.002275209,0.001151603,0.0008573344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007742268,0.000147893,0.9304903,0.0002074325,0.0004204957,0.0005639844,0.0004405421,0.0009682669,0.001989938,0.0005384827,0.04345794,0.02000045],"study_design_scores_gemma":[0.000190506,0.0001052762,0.968554,0.0001226826,0.0001398803,0.00114132,0.0003018258,0.001143861,0.0007907929,0.000242852,0.02722657,0.00004053768],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5787408,0.0009470825,0.002398845,0.0004796151,0.00003402653,0.0003927832,0.4143937,0.0003413526,0.00227186],"genre_scores_gemma":[0.4761722,0.000499576,0.008033558,0.0005036042,0.00008111799,0.0009060057,0.5122977,0.0002025786,0.001303725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03295095,"threshold_uncertainty_score":0.06551826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04856268561654192,"score_gpt":0.4266473426407179,"score_spread":0.3780846570241759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}