{"id":"W4409624683","doi":"10.1152/physiolgenomics.00174.2024","title":"A genetic variant associated with aquaporin 3 expression is correlated to in-hospital death in COVID-19 patients with extracellular hyperosmolality","year":2025,"lang":"en","type":"article","venue":"Physiological Genomics","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Lady Davis Institute for Medical Research; Canadian Institutes of Health Research; Njurfonden; Cancer Research UK; Vetenskapsrådet; Hjärt-Lungfonden; Svenska Läkaresällskapet; Knut och Alice Wallenbergs Stiftelse","keywords":"Genotype; Biology; Homeostasis; Aquaporin 3; Aquaporin; Odds ratio; Internal medicine; Cohort; Physiology; Bioinformatics; Endocrinology; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009756401,0.0001902713,0.0002224676,0.00005709029,0.00005474028,0.00001405829,0.0001500118,0.0002216472,0.00001511085],"category_scores_gemma":[0.00005271027,0.0001400733,0.00004085607,0.0002325681,0.00004456455,0.000005071156,0.00005390093,0.0001266063,0.000002587322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001112857,"about_ca_system_score_gemma":0.00009808574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004569841,"about_ca_topic_score_gemma":0.00004717503,"domain_scores_codex":[0.9988033,0.00006847154,0.0002625713,0.0004892014,0.000105901,0.0002705584],"domain_scores_gemma":[0.9995155,0.00001424924,0.00008083137,0.000220556,0.00005977469,0.0001091006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00233108,0.001778426,0.6788975,0.000035287,0.00007049694,0.00005093492,0.0004369974,0.02538117,0.2903482,0.00006454231,0.0002083929,0.0003969546],"study_design_scores_gemma":[0.002272072,0.0008647096,0.985716,0.00005937948,0.00001487029,3.848877e-7,0.00004375477,0.0003206184,0.009703493,0.0003799321,0.0003574728,0.0002673336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953252,0.0001074224,0.003845439,0.00008779894,0.00005422597,0.0005066219,0.00002629979,0.00001331232,0.00003366888],"genre_scores_gemma":[0.9985033,0.00002883333,0.0004858284,0.0004104041,0.000019899,0.00004693326,0.0004039421,0.00001279757,0.0000880806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3068185,"threshold_uncertainty_score":0.5712025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101930410092313,"score_gpt":0.2270113384280823,"score_spread":0.216818297418851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}