{"id":"W4409625028","doi":"10.1158/1538-7445.am2025-3503","title":"Abstract 3503: ZW171, a differentiated 2+1 T cell-engaging bispecific antibody with antitumor activity in a range of mesothelin-expressing cancers","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Mesothelin; Cancer research; Bispecific antibody; Medicine; Antibody; Oncology; Cancer; Internal medicine; Monoclonal antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514259,0.0004826121,0.0001512299,0.0002137025,0.00006768958,0.0001679081,0.0001900647,0.0002441679,0.001382082],"category_scores_gemma":[0.00007315501,0.00007348229,0.0001430053,0.0001165909,0.0001122202,0.0001404989,0.0001404938,0.0003827492,0.0003932506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003185682,"about_ca_system_score_gemma":0.0002333594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008166392,"about_ca_topic_score_gemma":0.0007454587,"domain_scores_codex":[0.9999104,0.00001434212,0.000006274185,0.00001732979,0.0000252897,0.00002633552],"domain_scores_gemma":[0.9999588,0.000004409311,0.000009515595,0.000003068839,0.000009890369,0.00001428753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001720065,0.00007343121,0.0002303974,0.00004801163,0.000008065561,0.00003104236,0.00001237413,0.0003978247,0.9953511,0.0001489869,0.0002136529,0.003313002],"study_design_scores_gemma":[0.00004844755,0.001199589,0.001128771,0.000006184991,0.00002081512,0.00020375,0.00001188724,0.001290903,0.9924037,0.00003112437,0.003651517,0.000003255533],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9923574,0.00144014,0.00304668,0.00009020947,0.00003251269,0.00007272492,0.0003871453,0.00009499022,0.00247813],"genre_scores_gemma":[0.9912202,0.0008323428,0.003004108,0.00009029241,0.000008933545,0.00007652093,0.001212802,0.00002709855,0.003527754],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001382082,"threshold_uncertainty_score":0.004623532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07131556111654894,"score_gpt":0.4300704647329971,"score_spread":0.3587549036164481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}