{"id":"W4409625280","doi":"10.1158/1538-7445.am2025-3012","title":"Abstract 3012: A highly potent selective CDK9 inhibitor OBP-004 reduces metastatic tumor burden in bone, brain, lung and lymph nodes and decreases growth of triple-negative breast cancer cells in bone","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Lymph; Medicine; Cancer; Cancer research; Lung; Breast cancer; Lung cancer; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008305705,0.0004200075,0.0003452891,0.0002840981,0.0001134579,0.0001826499,0.0002605071,0.0002638791,0.002975938],"category_scores_gemma":[0.00005698878,0.0001293672,0.0001848989,0.0002268787,0.0001315566,0.0001380577,0.0001093232,0.0005547079,0.0006554683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000214635,"about_ca_system_score_gemma":0.000340827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000878009,"about_ca_topic_score_gemma":0.001412244,"domain_scores_codex":[0.9999419,0.000009181281,0.000004041292,0.00001011981,0.00001798131,0.00001664747],"domain_scores_gemma":[0.9999714,0.000003422503,0.000005365448,0.000002489983,0.000003834393,0.00001357196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00128212,0.0005621269,0.0002707785,0.0001710639,0.00001923473,0.00009658615,0.00001146927,0.0002566609,0.9858024,0.0001041534,0.001033703,0.01038969],"study_design_scores_gemma":[0.0005666062,0.005119605,0.00443656,0.00001164664,0.00005424481,0.0006223942,0.0000185856,0.001299118,0.9789373,0.00006319981,0.008859324,0.00001143053],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9834426,0.005212469,0.002580796,0.0002934449,0.0001073956,0.0001620806,0.002170217,0.0003344522,0.005696613],"genre_scores_gemma":[0.9763367,0.003974183,0.002890915,0.0001678091,0.00002748222,0.0002087528,0.003975583,0.00004373686,0.01237483],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002975938,"threshold_uncertainty_score":0.009955525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828478172478375,"score_gpt":0.3899130281984032,"score_spread":0.3616282464736194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}