{"id":"W4409625684","doi":"10.1158/1538-7445.am2025-1704","title":"Abstract 1704: Overcoming resistance in HER2-positive gastric and breast cancers: Efficacy of disitamab vedotin in preclinical models resistant to trastuzumab emtansine and trastuzumab deruxtecan","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Trastuzumab; Medicine; Trastuzumab emtansine; Internal medicine; Oncology; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210879,0.0005343497,0.0004351049,0.0003783164,0.000143073,0.000248711,0.000318234,0.0003274903,0.001842292],"category_scores_gemma":[0.0001177189,0.0001248806,0.0002253078,0.0002242192,0.0001644985,0.0002724501,0.0001302566,0.0006809952,0.0002653641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004895696,"about_ca_system_score_gemma":0.0004133222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001400016,"about_ca_topic_score_gemma":0.002014182,"domain_scores_codex":[0.9998957,0.00002112013,0.000008867285,0.00001491461,0.00002935163,0.00003012975],"domain_scores_gemma":[0.9999366,0.00001095031,0.00001279873,0.000005635512,0.0000109882,0.00002305295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00206891,0.001335471,0.0008043455,0.0002115623,0.0000408277,0.0001016062,0.00003996151,0.0007268098,0.9806621,0.0002063946,0.000608084,0.0131939],"study_design_scores_gemma":[0.0005381667,0.01434251,0.004881016,0.00001433653,0.00007750033,0.0005283289,0.00002862084,0.001919628,0.9720053,0.00004843893,0.005606243,0.000009968569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948965,0.002137375,0.0006149033,0.0001344009,0.00004128533,0.00007967258,0.0003481721,0.00005674184,0.001691055],"genre_scores_gemma":[0.9906704,0.001750811,0.002485299,0.00007340094,0.00002448365,0.0001042003,0.001095567,0.00001953571,0.003776384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842292,"threshold_uncertainty_score":0.006163061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08495907479758326,"score_gpt":0.4509803038312007,"score_spread":0.3660212290336175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}