{"id":"W4409625751","doi":"10.1158/1538-7445.am2025-1277","title":"Abstract 1277: <i>Ex ovo</i> system for rapid and quantitative modelling of immunotherapy responses in pre-clinical and patient-derived xenografts: PDX<i>ovo</i>","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital","funders":"","keywords":"In ovo; Medicine; Immunotherapy; Ex vivo; Oncology; Internal medicine; Biology; Cancer; Genetics; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007207014,0.000455,0.0002773717,0.000355433,0.0002364377,0.0006817501,0.0005091121,0.0006748134,0.00627676],"category_scores_gemma":[0.0003464864,0.0002527406,0.0003027586,0.0002207299,0.0002881934,0.0003767361,0.0003494989,0.0008705416,0.002460266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005010215,"about_ca_system_score_gemma":0.0003131692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001605452,"about_ca_topic_score_gemma":0.001283054,"domain_scores_codex":[0.9997392,0.00003223637,0.0000253906,0.00006828873,0.0001035283,0.00003128687],"domain_scores_gemma":[0.9997782,0.00006752718,0.0000546194,0.00004218829,0.00003286302,0.00002458886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002154926,0.00006340347,0.0004812775,0.00008701589,0.000009326192,0.00006955478,0.00006715357,0.001479686,0.9918895,0.0006976674,0.001221369,0.00371847],"study_design_scores_gemma":[0.00006318465,0.000411734,0.002228471,0.00002266914,0.00002653414,0.0002497389,0.00002806595,0.01806012,0.954942,0.0001263311,0.0238219,0.00001919201],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7478713,0.001599526,0.1969084,0.0006414074,0.0004486275,0.001037406,0.02534684,0.005378296,0.02076818],"genre_scores_gemma":[0.8648857,0.001342014,0.09239957,0.0002444644,0.00004892311,0.001878156,0.01943938,0.001464122,0.01829763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00627676,"threshold_uncertainty_score":0.02099782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.10291293510158,"score_gpt":0.4119745433160171,"score_spread":0.3090616082144371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}