{"id":"W4409626118","doi":"10.1158/1538-7445.am2025-2123","title":"Abstract 2123: KJ-103: First-in-class naked anti-TROP2 HCAb with immune modulatory mechanisms and tumor regression potential in clinical trials","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Immune system; Medicine; Class (philosophy); Oncology; Internal medicine; Immunology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004418738,0.0004050136,0.0004316459,0.0002524834,0.000177694,0.0006111612,0.0003765702,0.0008511246,0.004396645],"category_scores_gemma":[0.0002236903,0.0001469176,0.0002329494,0.0002217747,0.0002385401,0.0004757393,0.000197533,0.001164339,0.001541169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00040432,"about_ca_system_score_gemma":0.0005858092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005135234,"about_ca_topic_score_gemma":0.001019899,"domain_scores_codex":[0.9998846,0.00002132193,0.000007847789,0.00001693597,0.00003352657,0.00003579701],"domain_scores_gemma":[0.9998492,0.00001262173,0.00002608247,0.000009659731,0.00002241513,0.00007999425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0293459,0.007755314,0.002158103,0.001631624,0.000461008,0.001014745,0.0002007713,0.001572159,0.5756035,0.00168436,0.02246679,0.3561057],"study_design_scores_gemma":[0.07363889,0.2427229,0.03299869,0.0005409248,0.001179327,0.009097961,0.0002110083,0.007104087,0.4154622,0.001590118,0.2152912,0.0001626958],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.935841,0.03394761,0.00517975,0.001997315,0.0007422576,0.001171588,0.002509447,0.0009457333,0.01766537],"genre_scores_gemma":[0.9656127,0.01206186,0.004158763,0.0014455,0.0001987391,0.0005107754,0.002970522,0.00008735195,0.01295365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004396645,"threshold_uncertainty_score":0.01470822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1037997744454655,"score_gpt":0.4694513717600073,"score_spread":0.3656515973145418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}