{"id":"W4409626158","doi":"10.1158/1538-7445.am2025-2874","title":"Abstract 2874: ZW327, a novel Ly6E-targeting antibody-drug conjugate bearing a topoisomerase 1 inhibitor payload","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Conjugate; Antibody-drug conjugate; Topoisomerase; Drug; Antibody; Medicine; Pharmacology; Biology; Monoclonal antibody; Immunology; DNA; Genetics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008945198,0.0003991166,0.0001632314,0.0001639142,0.00007516889,0.0001575151,0.0002157481,0.0003491825,0.002264345],"category_scores_gemma":[0.00007751593,0.00009986049,0.0001200474,0.0001043857,0.0001017793,0.0002269936,0.0001885006,0.0002663448,0.001158264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002375988,"about_ca_system_score_gemma":0.0001485896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002474484,"about_ca_topic_score_gemma":0.0001909945,"domain_scores_codex":[0.9999415,0.00001015533,0.000004783989,0.00001256115,0.00002156922,0.000009491856],"domain_scores_gemma":[0.9999779,0.000002095823,0.000007014962,0.000001525491,0.000005418004,0.000006044692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001227019,0.00003824907,0.00008998803,0.00007968476,0.000008015123,0.00008088876,0.000007102374,0.0001756464,0.9940328,0.0002415408,0.0002935866,0.004829854],"study_design_scores_gemma":[0.00004719594,0.0005299015,0.0005207933,0.000004960497,0.000009594767,0.0004836809,0.000004734125,0.0008664365,0.9902102,0.00003569611,0.0072827,0.000004123416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627314,0.005293055,0.01744174,0.0003270303,0.0001060682,0.0002174864,0.0007211649,0.0002970646,0.01286495],"genre_scores_gemma":[0.9767748,0.001829594,0.00691176,0.0001071031,0.00001946694,0.00007632125,0.001135119,0.00003631919,0.01310961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002264345,"threshold_uncertainty_score":0.007575035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08370463835081471,"score_gpt":0.4749974242732171,"score_spread":0.3912927859224024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}