{"id":"W4409626582","doi":"10.1158/1538-7445.am2025-4494","title":"Abstract 4494: Structure, dynamics and therapeutic potential of fatty acid synthase","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011441,0.0002057479,0.0001779184,0.0001246203,0.0001332028,0.0002360935,0.0001858502,0.0002572876,0.001912434],"category_scores_gemma":[0.00008970124,0.00008755475,0.0001736315,0.0001255516,0.0001249336,0.0001967673,0.0001179544,0.0002945103,0.0005612712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004039647,"about_ca_system_score_gemma":0.0002007548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004383685,"about_ca_topic_score_gemma":0.0002457073,"domain_scores_codex":[0.9999695,0.000004305203,0.000001862576,0.00000854619,0.000009868759,0.000005896795],"domain_scores_gemma":[0.9999734,0.000003062089,0.000007332545,0.000002204535,0.000003591435,0.00001034484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004166835,0.00006162434,0.001118228,0.0001061775,0.00002537932,0.0001741689,0.00002622461,0.003077672,0.981265,0.001218618,0.0004324146,0.01207781],"study_design_scores_gemma":[0.0001776509,0.001151641,0.009600912,0.00004891868,0.00005333296,0.001154297,0.00007623683,0.04670868,0.903715,0.002652094,0.0346141,0.00004712752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789479,0.01134024,0.005877606,0.0004851623,0.00008583781,0.00002953823,0.000564497,0.0001291572,0.002539998],"genre_scores_gemma":[0.9911274,0.002707691,0.002583177,0.00005357632,0.00001691731,0.00001678689,0.001056876,0.00001990628,0.002417711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001912434,"threshold_uncertainty_score":0.006397784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01989311376192977,"score_gpt":0.3547905949080828,"score_spread":0.334897481146153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}