{"id":"W4409626698","doi":"10.1158/1538-7445.am2025-4153","title":"Abstract 4153: Biomarker-driven polyamine pathway targeting as a treatment approach for TNBC","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Polyamine; Biomarker; Cancer research; Medicine; Computational biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009475302,0.0002349113,0.0002256402,0.0001845752,0.0001082181,0.0002708345,0.0001757659,0.0002642653,0.002594901],"category_scores_gemma":[0.00005092789,0.00007392227,0.0001599728,0.0001776992,0.0001092039,0.0001470451,0.0001581789,0.0005403972,0.0004497526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066065,"about_ca_system_score_gemma":0.0002676785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006149031,"about_ca_topic_score_gemma":0.001880242,"domain_scores_codex":[0.9999487,0.000008030702,0.00000389178,0.00001005877,0.00001744496,0.00001182983],"domain_scores_gemma":[0.9999692,0.000002855542,0.00000832689,0.000002690886,0.000005616611,0.00001126403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008010582,0.0003461599,0.0004871692,0.0002337572,0.00002384369,0.00009632901,0.00002286396,0.0001752096,0.9692811,0.0002690247,0.0006329792,0.02763062],"study_design_scores_gemma":[0.0005426324,0.01393277,0.01321673,0.00006973538,0.0001368925,0.0017306,0.00008307939,0.002122426,0.9308624,0.0002591834,0.0370203,0.00002328126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738253,0.01359222,0.003970426,0.0007342452,0.0002357033,0.0002703164,0.0007713599,0.0001959855,0.006404555],"genre_scores_gemma":[0.9830195,0.005181981,0.003765004,0.0003071949,0.00003907426,0.0001076635,0.000830305,0.00001800343,0.006731349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002594901,"threshold_uncertainty_score":0.008680761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06232397525916025,"score_gpt":0.3931167434171777,"score_spread":0.3307927681580175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}