{"id":"W4409626893","doi":"10.1158/1538-7445.am2025-2223","title":"Abstract 2223: Phase I clinical trial combining camu camu prebiotic enriched with castalagin modulates bile acids and metabolites in combination with cancer immunotherapy in patients with treatment-naïve lung cancer and PD-1 refractory melanoma (NCT05303493)","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Tannin, Tannase and Anticancer Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université Laval; Université de Sherbrooke; Concordia University; Hôpital Charles-Le Moyne; McGill University","funders":"","keywords":"Cancer; Lung cancer; Prebiotic; Medicine; Cancer research; Immunotherapy; Cancer immunotherapy; Clinical trial; Internal medicine; Oncology; Pharmacology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005569443,0.0003782139,0.0008033476,0.0005355901,0.0002230483,0.00008858326,0.0001710033,0.0002614124,0.0001159384],"category_scores_gemma":[0.00003752392,0.0002580161,0.00004187782,0.0006481619,0.0009106179,0.0003811102,0.00006584471,0.0008117035,8.322575e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005139885,"about_ca_system_score_gemma":0.001033125,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01380618,"about_ca_topic_score_gemma":0.00695511,"domain_scores_codex":[0.9973735,0.0004412804,0.0005025174,0.0007635747,0.0001791624,0.0007399952],"domain_scores_gemma":[0.9985887,0.0005955434,0.000179507,0.0003199353,0.0002499092,0.00006638472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06945527,0.001968776,0.8783392,0.0001374339,0.001016384,0.00003017427,0.002095577,0.00003686768,0.0118848,0.00008820317,0.00007542289,0.0348719],"study_design_scores_gemma":[0.1843082,0.005536724,0.7930978,0.0009730982,0.0001583416,0.000003040047,0.001182311,0.00005857653,0.01282262,0.00004430283,0.001318636,0.0004964036],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715105,0.02594026,0.000004656857,0.0003050111,0.0002266453,0.001720603,0.0001645444,0.00003995969,0.00008778803],"genre_scores_gemma":[0.9916418,0.006698936,0.0000171842,0.00005086432,0.0000379728,0.0008577965,0.00007543097,0.00005243232,0.0005675448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1148529,"threshold_uncertainty_score":0.9999872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03908393092619538,"score_gpt":0.4017521432704004,"score_spread":0.362668212344205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}