{"id":"W4409626893","doi":"10.1158/1538-7445.am2025-2223","title":"Abstract 2223: Phase I clinical trial combining camu camu prebiotic enriched with castalagin modulates bile acids and metabolites in combination with cancer immunotherapy in patients with treatment-naïve lung cancer and PD-1 refractory melanoma (NCT05303493)","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Tannin, Tannase and Anticancer Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université Laval; Université de Sherbrooke; Concordia University; Hôpital Charles-Le Moyne; McGill University","funders":"","keywords":"Cancer; Lung cancer; Prebiotic; Medicine; Cancer research; Immunotherapy; Cancer immunotherapy; Clinical trial; Internal medicine; Oncology; Pharmacology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007071304,0.0009957781,0.001521164,0.000280544,0.0004042795,0.0009136699,0.0006179511,0.001359926,0.007351413],"category_scores_gemma":[0.0003951576,0.0003822478,0.0009343539,0.0003350303,0.0005882033,0.0004704307,0.0002851841,0.002894666,0.001470902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007300538,"about_ca_system_score_gemma":0.001776898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001075605,"about_ca_topic_score_gemma":0.003475812,"domain_scores_codex":[0.999827,0.00006863123,0.000009813672,0.00002882842,0.00002060573,0.0000451851],"domain_scores_gemma":[0.9997373,0.00002684571,0.00005020013,0.0000244686,0.00002830771,0.0001328165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.672075,0.09208437,0.003045827,0.002358763,0.001558437,0.0002612545,0.0002437198,0.001830616,0.1237101,0.0004454321,0.01080859,0.09157789],"study_design_scores_gemma":[0.4612856,0.512918,0.007291018,0.0000856311,0.0005372805,0.0002159241,0.00007115708,0.0009930152,0.01064777,0.0002433761,0.005681842,0.00002950556],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798571,0.003276302,0.0006897637,0.0007821997,0.0002567288,0.006262487,0.00391801,0.00028803,0.004669436],"genre_scores_gemma":[0.9766487,0.002118042,0.001887121,0.001415745,0.0001918073,0.005673571,0.004375337,0.00005428542,0.0076354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007351413,"threshold_uncertainty_score":0.02459288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03908393092619538,"score_gpt":0.4017521432704004,"score_spread":0.362668212344205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}