{"id":"W4409628019","doi":"10.1158/1538-7445.am2025-2780","title":"Abstract 2780: Topoisomerase IIb binding underlies frequently mutated elements in cancer genomes","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research","funders":"","keywords":"Topoisomerase; Biology; Cancer; Genome; Genetics; Computational biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378402,0.0002027589,0.000194615,0.0007987361,0.0003342843,0.0004073723,0.0002098633,0.000349672,0.007689841],"category_scores_gemma":[0.0003690302,0.0001427476,0.0001594796,0.0005834203,0.000169515,0.0001450242,0.0003186821,0.0002812693,0.0009656432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003553107,"about_ca_system_score_gemma":0.0001705877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182596,"about_ca_topic_score_gemma":0.001717818,"domain_scores_codex":[0.9998593,0.00001521006,0.000008368644,0.00004123668,0.00004700923,0.00002886815],"domain_scores_gemma":[0.9998493,0.00002618316,0.00004769233,0.00001268729,0.00002131975,0.00004275643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004608695,0.00004693925,0.04379361,0.0001481093,0.0000741125,0.0007412893,0.0001015681,0.0004161944,0.9402623,0.001068297,0.00166605,0.01122072],"study_design_scores_gemma":[0.0000339189,0.0003078099,0.6456929,0.00003317531,0.0001138433,0.006271752,0.0003404388,0.003814105,0.3278092,0.00129809,0.01425899,0.00002581475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922411,0.0006724594,0.002233131,0.0001757852,0.00003013774,0.00001408908,0.001347113,0.0001836923,0.003102433],"genre_scores_gemma":[0.9949337,0.0002303355,0.00135945,0.00005640212,0.0000141651,0.00001016717,0.001180043,0.00002869291,0.002187165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007689841,"threshold_uncertainty_score":0.02572507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0759939413117744,"score_gpt":0.4336453895553297,"score_spread":0.3576514482435553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}