{"id":"W4409628296","doi":"10.1001/jamapediatrics.2025.0205","title":"Genomic and Developmental Models to Predict Cognitive and Adaptive Outcomes in Autistic Children","year":2025,"lang":"en","type":"article","venue":"JAMA Pediatrics","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Rivière-des-Prairies; McGill University; Hospital for Sick Children; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Montreal Neurological Institute and Hospital; SickKids Foundation; University of Toronto; HEC Montréal; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University Health Centre","funders":"Wellcome Trust","keywords":"Autism; Medicine; Generalizability theory; Autism spectrum disorder; Developmental disorder; Receiver operating characteristic; Intellectual disability; Vineland Adaptive Behavior Scale; Clinical psychology; Pediatrics; Psychiatry; Developmental psychology; Psychology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003137701,0.0009201676,0.0003411286,0.001702569,0.0002962598,0.0008710087,0.0004948016,0.0003805181,0.001615562],"category_scores_gemma":[0.009552806,0.0002601207,0.0007204325,0.0006060916,0.0003549026,0.0004289708,0.0009013531,0.0006520154,0.0002794493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008460932,"about_ca_system_score_gemma":0.0009655341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01382244,"about_ca_topic_score_gemma":0.01225354,"domain_scores_codex":[0.9994418,0.0002790276,0.00003756917,0.000126406,0.00006127442,0.00005399584],"domain_scores_gemma":[0.9962836,0.002797439,0.0004193754,0.0001467256,0.0002361854,0.0001167315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002859631,0.0001257211,0.8692999,0.00003557325,0.000349212,0.0002113256,0.0001850543,0.1007549,0.0002427722,0.0005166875,0.001144101,0.02684877],"study_design_scores_gemma":[0.00004358021,0.0002968857,0.200773,0.00008361525,0.0002319124,0.000402684,0.0002842763,0.7921051,0.0003818632,0.004471014,0.0008977329,0.00002837799],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977992,0.0004395227,0.01828459,0.0005334801,0.00001975035,0.00007124934,0.001103698,0.0002653604,0.001290413],"genre_scores_gemma":[0.9923632,0.0001271124,0.006139293,0.00003446091,0.000009828611,0.0000418546,0.0009464928,0.00001306226,0.0003247373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01382244,"threshold_uncertainty_score":0.02748394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0271159882497851,"score_gpt":0.2791703939772341,"score_spread":0.252054405727449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}