{"id":"W4409628296","doi":"10.1001/jamapediatrics.2025.0205","title":"Genomic and Developmental Models to Predict Cognitive and Adaptive Outcomes in Autistic Children","year":2025,"lang":"en","type":"article","venue":"JAMA Pediatrics","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Rivière-des-Prairies; McGill University; Hospital for Sick Children; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Montreal Neurological Institute and Hospital; SickKids Foundation; University of Toronto; HEC Montréal; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University Health Centre","funders":"Wellcome Trust","keywords":"Autism; Medicine; Generalizability theory; Autism spectrum disorder; Developmental disorder; Receiver operating characteristic; Intellectual disability; Vineland Adaptive Behavior Scale; Clinical psychology; Pediatrics; Psychiatry; Developmental psychology; Psychology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636805,0.0001581279,0.0002023052,0.0004809706,0.0001264607,0.00009808382,0.0001724848,0.00008050339,0.00001025956],"category_scores_gemma":[0.0007191539,0.0001576484,0.00001668797,0.0006349251,0.00009927707,0.0001889427,0.0005126387,0.0002764739,0.00003114458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001200665,"about_ca_system_score_gemma":0.0002058587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001349887,"about_ca_topic_score_gemma":0.00008615864,"domain_scores_codex":[0.9985691,0.00008548557,0.000210007,0.0005215268,0.0002481762,0.0003657522],"domain_scores_gemma":[0.9991675,0.0005992074,0.00003345037,0.00008497224,0.000010182,0.0001046614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001258043,0.0001048106,0.978443,0.00002349888,0.000009274835,0.0000341995,0.001580173,0.00005087036,0.000187247,0.01351592,0.0002139369,0.005711217],"study_design_scores_gemma":[0.001228094,0.00007876322,0.9856818,0.00001329717,0.00001710036,0.00001135087,0.000169271,0.002816,0.0001886002,0.009610445,0.00001075738,0.0001744988],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927979,0.0002374545,0.0016331,0.001380392,0.00004799441,0.0007820066,0.0001624613,0.0000422304,0.002916528],"genre_scores_gemma":[0.9980444,0.0003068825,0.0005387877,0.0006691565,0.00001861424,0.00005129764,0.000003163587,0.00001455476,0.0003530871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00723877,"threshold_uncertainty_score":0.6428716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0271159882497851,"score_gpt":0.2791703939772341,"score_spread":0.252054405727449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}