{"id":"W4409628314","doi":"10.1158/1538-7445.am2025-3243","title":"Abstract 3243: Fragmentomic features of plasma cell-free DNA in patients with osteosarcoma","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Osteosarcoma; Medicine; Cancer research; DNA; Internal medicine; Oncology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001426225,0.0002451469,0.0002098659,0.0007850571,0.0001511747,0.0002580709,0.0001666185,0.000384365,0.002223665],"category_scores_gemma":[0.0009247273,0.0001030669,0.0001800488,0.000562752,0.0001687094,0.000220348,0.0002038351,0.0002668213,0.0003925498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001374256,"about_ca_system_score_gemma":0.00008318181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005328155,"about_ca_topic_score_gemma":0.0004979353,"domain_scores_codex":[0.9998653,0.00001501049,0.0000179214,0.00003871346,0.00004356742,0.00001951407],"domain_scores_gemma":[0.9996818,0.00009446147,0.0001149396,0.00001744485,0.00004157774,0.0000497664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001712474,0.00006017223,0.8744113,0.00009682486,0.00007986105,0.001538308,0.0002535245,0.0006950356,0.101379,0.000127203,0.0005173992,0.01912891],"study_design_scores_gemma":[0.00002808756,0.0003730127,0.9819599,0.00001319814,0.00006300649,0.005093446,0.0001838125,0.002499887,0.008364672,0.0002529409,0.001152838,0.00001526301],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979993,0.0002284928,0.0006808722,0.00004171109,0.000004432901,0.00000778279,0.0006867178,0.00001881903,0.0003319476],"genre_scores_gemma":[0.9978174,0.00007190504,0.0008914596,0.00003535304,0.000007656074,0.0000105246,0.0009390925,0.000007398481,0.000219365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002223665,"threshold_uncertainty_score":0.007438898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116809009384959,"score_gpt":0.3037299179454832,"score_spread":0.2925618278516335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}