{"id":"W4409628836","doi":"10.1158/1538-7445.am2025-5412","title":"Abstract 5412: Developing combination therapies for telomerase-overexpressing cancers","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Telomerase; Medicine; Cancer research; Cancer; Oncology; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004784851,0.0007236528,0.0008480089,0.001115068,0.0002385654,0.0008782157,0.0006466127,0.0007040848,0.005930057],"category_scores_gemma":[0.0002338447,0.000238305,0.0006401961,0.0005805021,0.0001877652,0.000518367,0.0005845393,0.001451072,0.00159324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005494831,"about_ca_system_score_gemma":0.0004354167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00053606,"about_ca_topic_score_gemma":0.001510413,"domain_scores_codex":[0.9997608,0.00003713157,0.0000178834,0.00005121484,0.00009538281,0.00003758385],"domain_scores_gemma":[0.9998657,0.00001811775,0.00003158066,0.00001345517,0.00003089674,0.00004035432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001162762,0.001484834,0.001513059,0.001283607,0.0003104221,0.0004726216,0.00007722324,0.003145031,0.7144545,0.001443184,0.008930353,0.2657223],"study_design_scores_gemma":[0.002444579,0.01787594,0.00982129,0.0003510661,0.001138821,0.003096029,0.0001003271,0.01029514,0.7467627,0.00122649,0.2067754,0.0001121702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7657951,0.1213439,0.0504554,0.004424716,0.001355871,0.002759475,0.005643819,0.002111372,0.04611033],"genre_scores_gemma":[0.8947122,0.04306228,0.03395138,0.001521434,0.0003119548,0.001329163,0.004370207,0.0002028643,0.02053859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005930057,"threshold_uncertainty_score":0.01983804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1204048170633287,"score_gpt":0.456984695812989,"score_spread":0.3365798787496603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}