{"id":"W4409629189","doi":"10.1158/1538-7445.am2025-4289","title":"Abstract 4289: Discovery of potent RAD51 inhibitors with anticancer activity in preclinical models of non-small cell lung cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University Health Network","funders":"","keywords":"Cancer; Medicine; Lung cancer; Pharmacology; Cancer research; Computational biology; Oncology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001962203,0.0006346932,0.0005712362,0.000336356,0.0001447262,0.0003155741,0.0004074655,0.0003667093,0.002665731],"category_scores_gemma":[0.0001140469,0.0002118789,0.0003114782,0.0002858718,0.0001432056,0.0002199662,0.000198476,0.0008267263,0.001104956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548181,"about_ca_system_score_gemma":0.0004590816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007903249,"about_ca_topic_score_gemma":0.001798705,"domain_scores_codex":[0.9998996,0.00001548895,0.000008942186,0.00001861229,0.00002995761,0.00002741232],"domain_scores_gemma":[0.9999436,0.000006196187,0.00001085402,0.000006290325,0.00001177697,0.00002129689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000511318,0.0008965788,0.000460992,0.0003316048,0.00004243867,0.0002943634,0.00004743926,0.0009136203,0.9665399,0.0007599129,0.001777467,0.02742451],"study_design_scores_gemma":[0.001083145,0.01376864,0.01028654,0.00007731334,0.0001639503,0.001335617,0.00004324846,0.00328721,0.9301949,0.0002644758,0.03944991,0.0000450111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9536947,0.01720512,0.008381354,0.000632824,0.0002354279,0.0008494299,0.003207906,0.000463018,0.01533022],"genre_scores_gemma":[0.9569348,0.01488762,0.008807166,0.0005471485,0.00007372402,0.0003341508,0.005366471,0.00007407605,0.01297488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002665731,"threshold_uncertainty_score":0.008917749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06628005333678891,"score_gpt":0.4632152967950916,"score_spread":0.3969352434583027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}